Did you know that you can characterise DNA-protein complexes with #massphotometry? In a recent preprint, mass photometry helped shed light on the interaction dependencies between the Dna2 helicase-nuclease and replication protein A. Read more here - researchsquare.com/article/rs-358…

This, made me smile.. 😊

Single-molecule Fluorescence Technique to Monitor the Co-transcriptional Formation of G-quadruplex and R-loop Structures dlvr.it/S4m42H

Very thrilled to anounce that our review has been accepted in Frontiers - Genetics. The manuscript will be online soon 🎉🎉. frontiersin.org/articles/10.33…

This! Jennifer Cobb

Well said. Please follow the lead of other Canadian Universities U Calgary Teri Balser so faculty can safely teach in person without fear of bringing home COVID to their unvaccinated child. Or immunocompromised parent. So many reasons....to put vaccine and mask mandates in place.

Very happy to share our paper on a new physical interaction of BLM with MCM in unperturbed G1 and S. Untethering Blm/Mcm6 leads to supra-normal replication speed that requires Blm ATPase activity. Congrats to two amazing 🙌 grad students. Details in: academic.oup.com/nar/advance-ar…

Here is a summary of the latest #COVID19AB numbers: There are currently 284 people in hospital due to COVID-19. Of the 225 non-ICU, 80% are unvaccinated or partially vaccinated. Of the 59 in ICU, 98.3% are unvaccinated or partially vaccinated. (1/4)

New work from the lab showing that upon appearance of DNA breaks RNA editing by ADARs contributes to fine tune the response. Among other things, it helps to remove DNA:RNA hybrids to expedite DNA resection. Read the whole story at ⁦Nature Communications⁩ nature.com/articles/s4146…

Check out our Jennifer Cobb work that provides insight about age-related molecular changes in DSB repair, where both canonical pathways - HR and NHEJ become disrupted and cells gradually move towards error-prone DSB repair increasing the mutational burden. biorxiv.org/content/10.110…

Doing good science is finding the right balance between thinking small: obsessing over the minute details of a problem by mastering a given set of tools & thinking big: being receptive to having new (often strange) ideas from outside your field change how you think of a problem.

As someone who is a slow thinker I've always thought we in science put too much emphasis on fast thinking, Q&As, chalk talks, thesis exams, many classroom interactions are geared towards rewarding speed. But in science what matters is not who thinks fastest but who thinks deepest

1/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. Jennifer Cobb Journal of Biological Chemistry Nej1 interacts with Sae2 at DNA double-stranded breaks to inhibit DNA resection jbc.org/article/S0021-…

2/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. Jennifer Cobb DNA Repair Multifunctional properties of Nej1XLF C-terminus promote end-joining a... sciencedirect.com/science/articl…

3/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. Jennifer Cobb Journal of Molecular Biology Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations. sciencedirect.com/science/articl…

1/2 Happy to share our latest study in Cell Reports from Bartek Lab ! We unveil a role for MDC1 in transcription by regulating RNA Pol II! Huge congrats to our talented PhD student Georgios Pappas cell.com/cell-reports/f…

Another layer of the complex interplay of DSB repair factors revealed in this new study from our lab with Jennifer Cobb UniversityOfVictoria BC yeast_papers bioRxiv #DSBRepair #NHEJ #altEJ biorxiv.org/content/10.110…

📢1 WEEK TO GO📢 The registration and poster abstract submission deadlines for #Genreg24 are on Monday 11th December 2023. Register and submit your abstract now to join us in Mexico in February! 🇲🇽☀️

This study from our lab reveals a Cross talk of the two main nucleases in maintaining the genomic integrity. Jennifer Cobb Dept. of Biochemistry & Microbiology at UVic Journal of Biological Chemistry

A new report from our lab Jennifer Cobb Dept. of Biochemistry & Microbiology at UVic shows that the transiently formed RNA:DNA hybrids at DNA double-strand breaks regulate end resection and promote EJ. Dna2 nuclease removes these hybrids and enables resection at DSB. bioRxiv biorxiv.org/content/10.110…