“As a result, the company will better understand the precise manner in which therapeutics interact with their intended targets, accelerating drug discovery processes and providing a competitive advantage in the de novo therapeutic protein field.” #CryoEM #drugdiscovery #biologics

“This is really about re-imagining structural biology at scale,” Grigoryan said. “What could we do if it was just as easy to get the structure of a protein you’re working with as sequencing a piece of DNA?” #cryoEM #drugdiscovery #biotech

As promised, I've got our #IMC20 poster ready to go! If you're at the conference, swing by and say hi. Got questions? Feel free to ask!

Our structure biology and protein design team embedded within the vibrant scientific environment of Large Molecules Research at Sanofi in Cambridge Crossing, MA has an exciting postdoc opportunity to accelerate the development of next generation biologics. #postdocjobs #postdoc

My indispensable right hand Natalya Dudkina is hiring, join our exciting R&D group at Thermo Fisher Scientific as Application Engineer, Cryo-EM. RT please! jobs.thermofisher.com/GmABVUk

Excited to share our preprint: “Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase” in which we obtained a structure of a 46-kDa membrane protein to 2.2 Å resolution without fiducials. tinyurl.com/zycuw3p6

#Cryoem #ai #drugdiscovery

Didn't think I would ever post ApoF, but here we go. First couple hours of test data collection on our new Tundra. How easy was that! And the best part: it's not hidden in a basement, but on the 3rd floor, one flight of stairs away from the office :D

This fantastic story is out on structural analysis of NLRP3 inflammasome activation. Happy to be part of it! Please check it out! nature.com/articles/s4146…

Time-resolved cryo-EM of G-protein activation by a GPCR | Nature disq.us/t/4nd6xsj

Update on our kinase domain side project (37 kDa with a ligand): Previous sample had severe preferred orientation issues, pausing the project. Now back at it with new 2D classification results. Still preferred orientation persists, but we're optimistic about getting a map. #TGIF

Check out our new work by fabulous grad student Rodrigo NaturalSciences @ UT Molecular Biosciences! Guide RNA folds into gnarly geometry to tether tiny protein domains together. Fun collaboration with Metagenomi! DNA targeting by compact Cas9d and its resurrected ancestor biorxiv.org/content/10.110…

New paper out in bioarxiv!. In collaboration with the team of Maks Ovsjanikov, Vincent Mallet developed an algorithm that is available as a plug-in for ChimeraX (bsky: chimerax.ucsf.edu) to find antibodies and nanobodies, within seconds, in #cryoem densities. biorxiv.org/content/10.110…. Try it out!

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…

Structural characterization of two full length γδTCR/CD3 complexes | bioRxiv biorxiv.org/content/10.110…

Four case studies are presented in which rationally designed surface modifications were key to establishing crystallization conditions for the target proteins Structural Biology IUCr #SurfaceModification #SurfaceEntropyReduction #CrystalPacking doi.org/10.1107/S20597…

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1 dlvr.it/TMMdLz

We’re scaling structure as a core capability in AI-native drug design. #TeamGenerate is searching for an Executive Director of CryoEM to lead a multidisciplinary team operating within one of the most advanced high-throughput structural biology platforms in the world. Reporting

In 216 ligand-bound structures of human FABP isoforms, many at better than 1.2 Å resolution, an estimated 15% of the ligands had a different chemical composition to that expected  #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S20597…