In a new study (biorxiv.org/content/10.110…), we have completely mapped mutations to #SARSCoV2 that escape human antibodies, and shown that these "escape maps" predict how virus evolves under antibody pressure & inform design of escape-resistant antibody cocktails. (1/12)

I've long advocated the use of DMS-approaches to understand escape from monoclonal and pooled antibodies during their development as antiviral therapeutics, as well as during viral surveillance to guide their clinical use. Here's a great example why! science.sciencemag.org/content/early/…

Today is a good day.

Half a million Americans have died of COVID-19. I wrote for The New Yorker about what this terrible milestone tells us, and what we still have to learn. newyorker.com/science/elemen…

We have completely mapped #SARS_CoV_2 mutations that escape binding by LY-CoV555 (antibody that forms the basis for Eli Lilly's bamlanivimab) both alone & in cocktail with LY-CoV016 in a new study led by Tyler Starr w/ Allie Greaney & Adam Dingens, PhD, MS: biorxiv.org/content/10.110… (1/n)

Come join my team at Shape TX, working at the interface of virology, functional genomics, and the next generation of RNA therapies! boards.greenhouse.io/shapetherapeut…

We've created an interactive website to visualize >100,000 experimental measurements of how mutations to #SARSCoV2 RBD affect binding by antibodies & sera: jbloomlab.github.io/SARS2_RBD_Ab_e… Explore it to examine a wealth of information about the antigenic effects of viral mutations. (1/n)

Being published in Cell, this must be a cruel April Fools Joke. Having is behind a paywall is the kicker! cell.com/cell/fulltext/…

Very happy to share that I wrote a review with Keith Jerome and Dan Stone (VIDD FHCRC) about the exciting developments in the field of AAV vector engineering to target organs/tissues that can harbor viral reservoirs! 🎉🎉🎉

Awesome to see more high-throughput antibody escape tech come on board, particularly from industry - where resulting data can more quickly be used to evaluate, engineer, and pool mAbs under clinical development. Great job A-Alpha Bio !

India’s COVID crisis flags need to forecast variants nature.com/articles/d4158…

FL77 is hiring multiple roles across many experience levels. Come develop the next generation of vaccines at a cutting edge, rapidly growing, and well-funded startup! Please RT! linkedin.com/jobs/search/?f…

I passed my thesis defense yesterday, “Understanding #SARSCoV2 antigenic drift using complete genotype-to-phenotype maps.” It has been an absolute privilege to be a graduate student in the Bloom Lab at the Fred Hutch Cancer Center and University of Washington - MSTP.