1/6 New Article Alert Hot in @BMJ_Oncology, our prospective study investigates the 🤔 #Bladdercancer treatment dilemma: 🔪 Radical cystectomy vs 🎯 Bladder preservation have Similar survival, but what about QOL? Tata Memorial Hospital TMC Radiation Oncology Sheetal R Kashid

NIPPON (JCOG2007): Chemo + pembro vs chemo + nivo–ipi as 1st line Tx for #NSCLC. OncoAlert ❌ No difference in PFS/OS 🏥Terminated early due to safety issues (7% treatment-related deaths w/ nivo/ipi) ➡️ underpowered to derive a definitive conclusion and for robust key

Performance of Low-Dose Immunotherapy and Standard-Dose Immunotherapy in Microsatellite Instability-High Metastatic Colorectal Cancer: Real-World Data (CLouD—High Study) | JCO Global Oncology ascopubs.org/doi/full/10.12… Anant Ramaswamy Viraj Lavingia Aditya Dhanawat

Incidence of MRONJ in patients with breast cancer - ⌛️ 20 year follow-up (most of the trials and data available so far has shorter follow-up) 💡MRONJ in patients on Denosumab - 11.6% 🤯 ✅ Dental eval must prior to anti-resorptive Rx ⁦OncoAlert⁩ ascopubs.org/doi/10.1200/JC…

Interesting trial of SBRT for oligoprogressive cancers - Initially planned for NSCLC patients, but due to poor accrual, included all histologies! 35% in SoC arm treated with SBRT ➡️ unwillingness to forgo ablative treatments on SoC arm! ⁦TMC Radiation Oncology⁩ redjournal.org/article/S0360-…

Treatment algorithm for HR+/HER2- MBC from JCO Oncology Practice #MedX ascopubs.org/doi/10.1200/OP…

Molecular biology of clear cell #renalcancer and interaction of VHL protein and HIF subunits JAMA Tracy Rose #Urology #GUOncology

SCLC with intact TP53 and RB in never/light smokers - Chromothripsis mediated SCLC #MedX #ThoracicOnco Dr Akhil Kapoor

Nicely summed up all the excellent work at Tata Memorial Hospital and across all departments. Quality, Consistency, Accuracy and Research inspite of huge patient volumes. Students asking why one should select TMH for training, all answers here! Vedang Murthy

It takes >3-4 weeks of steroids (@ any dose >5 mg pred/d) to pose risk of adrenal insufficiency – Hence, Endocrine Society Guideline says short-term glucocorticoid therapy of <3-4 wks, irrespective of dose, DOES NOT require GC tapering buff.ly/4gggMq6

Mechanisms of resistance to anti-oestrogen + CDK4/6i NatureRevClinOncol #breastcancer

Ifosfamide Can cause encephalopathy especially in patients with hypoalbuminemia. IV albumin prophylaxis. IV methylene blue treatment. Ifos can cause Type II RTA with NAG acidosis, hypokalemia, hypophosphatemia & Fanconi type proteinuria and glucosuria. MESNA cannot prevent this.

The first history a doctor writes should be the patient's health encyclopaedia, always accurate to look back on.

We may discuss about colon cancer screening in India, but unfortunately the fact remains that we still miss diagnosing them at earlier stages as the cause of iron deficiency anemia is not investigated, particularly in the elderly. #coloncancer

Two important things in life as described by Morgan Housel : patience & scarcity. Patience to let something grow. Scarcity to admire what it grows into. #SameAsEver #nowreading

A lot of things don’t compute!

“We promise according to our hopes and perform according to our fears." #QuoteForTheDay - François de La Rochefoucauld