Congratulations, Sarah K. Tasian & Andrei Thomas-Tikhonenko, on the Blood Cancer Discovery Award for Outstanding Journal Article. Drs. Tasian & Thomas-Tikhonenko are pictured with Deputy Editor Tanya Bondar. Learn more: bit.ly/3wbUROB Andrei Thomas-T.
#AACR24

Motivation Monday! Check out these brilliant studies from David DeNardo WUSM Sheila Stewart hot off the press focused on tissue-specific, immune-modulatory fxns of senescent CAFs! 🤩

April is just about over - what a month! It was so exciting to hear all the positive words about the special issue of Cancer Discovery at #AACR24 ! Don't miss all the special commentaries, Hallmarks of Precancer, and MUCH more - what was your favorite? aacrjournals.org/cancerdiscover…

Temporal #transcriptome profiling of the immune microenvironment in breast cancer bone metastasis revealed key communication pathways between dysfunctional T cells and myeloid-derived suppressor cells. Cancer Discovery #Oncology #genomics #MedEd #MedX #News

This study elucidates the function of ENL mutations in chromatin regulation and tumorigenesis, and demonstrates the potential of targeting pathogenic condensates in cancer treatment. Cancer Discovery #Cancer #Cancer Research #Oncology #science #MedEd #MedX

Read a Special Commentary from the April issue—
Tumor-Host Co-Metabolism Collaborates to Shape Cancer Immunity, by Yingcheng Wu, Qiang Zou, Peng Jiang, and Qiang Gao.
bit.ly/4aTr2kN
Fudan University

Read a Special Commentary from the April issue—
Elucidating the Cell Surfaceome to Accelerate Drug Development, by Jacob Geri and William Pao.
bit.ly/4dlYXEG

Our paper is out Cancer Discovery! We found ways to improve Pola-V on-target efficacy and used Pola-V as a tool to study the B-Cell Receptor.

A collaborative effort between Louis Staudt and Dan Hodson through NIHOxCam National Cancer Institute Cambridge University by way of BU MD/PhD Program

aacrjournals.org/cancerdiscover…

Read a Special Commentary from the April issue—
Chemotherapy and the Extra-tumor Immune Microenvironment: EXTRA-TIME, by Phan Lab, K. Weilbaecher, R. Aft, P. Croucher, & Christine Chaffer.
bit.ly/4dmhDDW
Garvan Institute of Medical Research UNSW UNSWMedicine UNSWScience Washington U. Med WashU Surgery

Read a Special Commentary from the April issue—
#Glioblastoma : Not Just Another Cancer, by Howard Fine.
bit.ly/3Uf6kF0
Weill Cornell Medicine Weill Cornell Neurology

Congrats Sheila Stewart and David DeNardo WUSM and colleagues on these timely and important studies on senescent fibroblasts mediating immune suppression in cancer! Can't wait to dive in.

Congratulations, Direna Alonso-Curbelo, on the inaugural Cancer Discovery Early Career Award! Dr. Alonso-Curbelo is pictured with in-house editors Elizabeth McKenna, Bailee Sliker, Ph.D, Tali Lev, & Robert Kruger & Editor-in-Chief Luis Diaz. Learn more:
bit.ly/3Ud9wkk
IRB Barcelona

Elizabeth McKenna Cancer Discovery Sheila Stewart David DeNardo WUSM Jennifer Jiayu Ye Jad Belle Washington U. Med Siteman Cancer Center Team work makes the dream work!! Beautiful stuff

👏👏👏

Congratulations to Bell and Yi on back to back Cancer Discovery papers. Go Sheila Stewart and Siteman Cancer Center
aacrjournals.org/cancerdiscover…

Turns our MyCAFs become Senescent (SenCAFs) and can drive both breast and pancreas cancer progression through immune modulation. See just now online at Cancer Discovery
aacrjournals.org/cancerdiscover…
aacrjournals.org/cancerdiscover…

And senCAFs are differ in the pancreas! Yup, tissues ARE different. @CD_AARC wotj David DeNardo WUSM

aacrjournals.org/cancerdiscover…

Check it out-the world of CAFs is more complex-senescent CAFs (senCAFs) drive breast cancer progression by inhibiting NK cells @CD_ AACR.

aacrjournals.org/cancerdiscover…