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GERMLINE: black patients undergoing multigene testing for heritable cancer had fewer pathogenic variants and more variants of unknown significance compared with white patients, likely reflecting under-representation in databases and research projects. ascopubs.org/doi/abs/10.120…

#HereditaryLive has started! Driving home or at work but have spare moment. Join and listen to live case presentations! 👉tinyurl.com/pwbbby68 Dr. Arora Josie Baker

‼️Reminder‼️ 🚨Upcoming deadline - Friday, August 23 to apply for these grants: ➡️#CGAIGC & Fight Colorectal Cancer Early Career Award ➡️#CGAIGC #Research Award 👍opportunity to get #research funded that will advance the care of🧑‍🤝‍🧑& 👪w/ #hereditary #cancer syndromes #GIFellow #GITwitter

August is #AppendixCancerAwarenessMonth! Our👍Comms Cttee members Michelle Springer & Anna Strang, MS, CGC (she/her) are shining the🔦on the📑 "Impact of Germline Alterations in #Appendiceal Adenocarcinoma" Their insightful📜👉tinyurl.com/yr2ax87u incl🗝️takeaways by Mike Foote from this study

📢Our Research grant deadline has been extended‼️ ➡️Couldn't make today's deadline? You now have another 7⃣ days to submit your #research project‼️ 🚨NEW Deadline is Friday, August 30, 2024🚨 ▶️Learn more & apply here👉cgaigc.com/grant-opportun… #HereditaryGICancer #GIFellow

1/Welcome to #CGAIGCJS Tweetorial on “Disparate Rates of Germline Variants in Ca Predisposition Genes in African🇺🇸/Black Compared w/ Non-Hispanic White Indivs. Btw 2015 & 2022” by #CGAIGC Comms Cttee member Ed Esplin, MD, PhD Full📑in #JCOPrecisionOncology👉 tinyurl.com/yc5jrmc5 🧵

🫁201 selected patients with #lungcancer were offered germline testing. Pathogenic germline variants were identified mainly in #ATM (n=4), #TP53 (3) and #BRCA2 (3). All TP53-associated cancer had somatic #EGFR activating variants. sciencedirect.com/science/articl… #hereditarycancer

Consider #germline #genetictesting for all #patients w/ #lungcancer c/w Sorscher et al. ascopubs.org/doi/10.1200/PO… JCO Precision Oncology Invitae & Jewel Samadder et al. jamanetwork.com/journals/jamao… JAMA Oncology Mayo Clinic Where 14% of unselected #lungcancer #patients had PGVs, enriched for DDR

Up to 17% of #prostatecancer #PC #patients have PGVs w/ #germlinetesting 36% of universally tested #PC #patients had positive health outcomes 2/2 #genetictesting results Shore et al. auajournals.org/doi/10.1097/JU… Journal of Urology Amer. Urol. Assn. #PROCLAIM NCT05447637 Invitae Labcorp

📢Your last opportunity to apply for the Fight Colorectal Cancer -#CGAIGC Early Career Award‼️ 🎯$15k to kick start your career for focus on: ➡️research ➡️quality improvement ➡️community projects for: 🧬#hereditary 🧬#familial or 🧬#eoCRC 👉🔗cgaigc.com/grant-opportun… #GITwitter #GIFellows

Completely agree. This despite the fact that National Comprehensive Cancer Network (NCCN) states at the bottom of every page of each of their guidelines, "National Comprehensive Cancer Network (NCCN) believes that the best management of any #patient with #cancer is in a #clinicaltrial. Participation in #clinicaltrials is especially encouraged."⬇️⬇️

Physicians made #treatment/#management changes for 3%/17% of #prostatecancer #patients using results from #universal #germline #genetictesting, including 11% of positive #patients with low-grade, #localizeddisease auajournals.org/doi/10.1097/JU… Journal of Urology Amer. Urol. Assn. Invitae

Ed Esplin, MD, PhD Journal of Urology Amer. Urol. Assn. Invitae Labcorp We would like to inform you that your post has been successfully published on @Oncodaily. Thank you for sharing such valuable data! oncodaily.com/blog/134045

Clinician Responses to Germline Genetic Testing in Prostate Cancer Management - Ed Esplin, MD, PhD Journal of Urology Amer. Urol. Assn. oncodaily.com/blog/134045 #Cancer #ProstateCancer #GeneticTesting #MedX #OncoDaily #Oncology

...for 26% of all #prostatecancer #patients & 57% of positive #patients, clinicians indicated #universal #germline #genetictesting (GGT) results may influence future treatment decisions should the #patient’s condition change. Shore et al. auajournals.org/doi/10.1097/JU… Journal of Urology

📢September is also #ChildhoodCancerAwarenessMonth ➡️Our Comms Cttee member Chandrika Kurpad, MS, LCGC has written a👍 📜highlighting the recent📑in The Lancet Oncology abt the groundbreaking study revealing new insights into the #rarecancer syndrome #CMMRD 📌Read the📜👉tinyurl.com/3p3npsw7

📢Our Executive Council elections are OPEN! 📌Meet our nominees🙌 🌟Sanjeevani Arora, PhD 🌟Pooja Dharwadkar, MD 🌟Christine Drogan, MS, LCGC 🌟Jessica Long, MS, CGC 🌟Gautam Mankaney, MD 🌟Joshua Sommovilla, MD ➡️As a #CGAIGC member, YOU can VOTE! Check your 📩for details‼️

"...#universal #genetictesting identifies actionable #germline pathogenic variants in more than 1:20 #patients w/ newly diagnosed #breastcancer & is associated w/ #systemictherapy recommendations in 1/3 of these cases." jamanetwork.com/journals/jaman… JAMA Network Open c/w Pat Whitworth

📢Stay tuned for another insightful📜post from our Comms Cttee member Chandrika Kurpad, MS, LCGC ➡️Next week, her blog post will be for #GynecologicCancerAwarenessMonth & focus on "Serous #UterineCancer: An Overview of #Genetics, Racial Disparities & Current Research" #HereditaryGICancer #GCAM