Less is more wins again. RCT of high MAP target in older adults w/sepsis, stopped early for harm, 39% mortality MAP 80-85 vs. 29% mortality MAP 65-70 link.springer.com/article/10.100…. Recall also that the 65 Trial hinted that MAP60 may be better than 65. How low can we go?

Fully agree with this. Sadly the The Royal College residency program requirements require each resident to make their 'own' research project - mostly low quality single centre observational studies or surveys - rather than encouraging multi centre collaborative RCTs.