In collaboration with Silvia Daun and Mahan Hosseini we developed a new python-based toolbox (AutoGaitA) for the automated analysis of locomotion. We applied cross-species and cross-tasks to start telling a tale of mice, of men and of flies. @CRC1451 biorxiv.org/content/10.110…

Injury distance limits the transcriptional response to spinal injury biorxiv.org/cgi/content/sh… #biorxiv_neursci

See our latest preprint! Sometimes it's what DOESN'T happen that matters most. Meaning - in the Mysterious Case of the Axons That Won't Regenerate, there is a dog that didn't bark. Great collab with Ishwariya Venkatesh Gemistos Plethon doi.org/10.1101/2024.0…

Hive mind of anatomy twitter, what is this bone I am holding? (Guessing seal origin but could be wrong, Northumberland coast April '24). Prof Alice Roberts💙

🚨Postdoc opening in the lab!!! If you are interested in dissecting the peripheral and spinal circuits involved in chemotherapy-induced neuropathy, email me your CV, cover letter, and references as one pdf file. Deadline 31 August 2024!

WebAtlas for visualising single cell & spatial data online is out: rdcu.be/dRsKu With Muzlifah Haniffa Tong LI 李彤 Dave Horsfall+co, we aimed to open up sc/spatial data to biologists & clinicians without coding experience/infrastructure. Rambling🧵on why this matters

👀Ft. Supp 3 for some high res dendritic spines in spinal cord dorsal horn! 👀 In vivo imaging adult spinal cord at depth remains tricky with all that myelin in the way, but 3P helps resolve fine structures.

Come and join us!!!

😮😮😮Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

Please RT: Job alter! We're looking for a postdoc working at the interface of developmental neurobiology & mechanobiology.If you want to figure out how local tissue mechanics interacts with chemical signals to regulate brain folding, apply! European Research Council (ERC) nature.com/naturecareers/…

Phantastic talk by previous PhD student at @charite now postdoc @Bradke lab @DZNE JULIANE SCHIWECK. Injured brain cells modelled in 3D at great spatial temporal resolution. #astrocyte #glia Last talk of #EMBO workshop on „Axonal Degeneration and Regeneration“ in Okinawa, Japan

My TV screensaver suggests "memories". A lovely throwback to the time spiny frogs were not spinal cords.

Spotlight on Single-Cell Genomics! We (Ozgun Gokce , Omer Ali Bayraktar, Naomi Habib - Habib Lab 💔, Genevieve Konopka, Shane Liddelow 🍊 , and Nowakowski_Lab) collaborating with top neuroscientists to explore optimizing these technologies: 🔗 nature.com/neuro/volumes/…

Segment Anything for Microscopy (μSAM) is based on Segment Anything, the vision transformer model for image segmentation, and offers generalist models for light and electron microscopy segmentation tasks. Constantin Pape Anwai Archit Genevieve Buckley Sushmita Nair nature.com/articles/s4159…

#futurePIgoals

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration biorxiv.org/content/10.110…

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Our paper is finally out on our experimentally-driven neuromechanical model to explain how spinal inhibition makes you do things faster! cell.com/cell-reports/f…

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.