While Ollie doesn't seem particularly concerned, I find the continued detection of HPAI (H5N1) in cats without known epi links to dairy cattle fairly alarming. Thanks to those that are rapidly testing, sequencing, and sharing data for the ongoing outbreak!

Unsurprisingly, the PB2 segment of the recent human H5N1 case from Michigan is nearly identical to the dairy cattle sequences from Michigan. I'm looking forward to comparing diversity across the entire genome when the Nextstrain build is updated! nextstrain.org/avian-flu/h5n1…

Data from the human H5N2 case from Mexico are now available on GISAID. Here's an HA tree built using Nextclade, with all human H5 cases from GISAID highlighted. Unsurprisingly, this seq belongs to the Am-nonGsGd clade, and is very distinct from the dairy cattle outbreak in the US

Fantastic opinion piece on H5N1 by some of my former mentors. "Set politics aside. Focus on a sustainable, science-driven solution. Act now before it is too late." scientificamerican.com/article/the-da…

Check out UShER for H5N1! Thanks to Angie Hinrichs and team for enabling rapid genomic epi analysis🦠🧬

Interested in joining our team? We currently have several positions open, but we'll be closing them soon. Learn more here: theiagen.com/news/join-thei… #Bioinformatics #Informatics #DataScientist

The answer to his question is simple. You can’t stop transmission when you don’t know where the virus is. That’s why we keep seeing cases. That’s why this outbreak is not containable, at least given the current response. That’s why we will see more cases going forward.

Great statement from the American Association of Avian Pathologists on the inadequate response to H5N1 (B3.13) in dairy cattle, and improvements needed to protect poultry and human health aaap.memberclicks.net/assets/Positio…

Congratulations to Rahil Ryder and Emily Smith and all co-authors - great work reviewing sequence data for SARS-CoV-2 recombinants in California!! Viruses MDPI mdpi.com/1999-4915/16/8…

📢 We're excited to introduce Pathoplexus, a specialized sequence database for human viral pathogens! 🌍 🧬 Launching with 4 viruses, Pathoplexus.org combines modern open-source software with transparent governance to improve global pathogen sequence sharing. 1/14

Nice thread on the sequence data from the recent H5N1 case from Missouri and associated limitations

Nice analysis on the recent human H5N1 cases from California!

Ollie and I would like to remind everyone today that public health saves lives 🦠📈🧬

Hopefully samples will be sequenced to help identify potential sources for those cats without exposure to raw milk, and to monitor ongoing evolution across different hosts!

Incredible effort by the CIDRAP CWD team!

Near Real-Time Genomic Characterization of the 2025 Sudan Ebolavirus Outbreak in Uganda’s Index Case: Insights into Evolutionary Origins virological.org/t/near-real-ti… Rapid sequencing of the outbreak genome by team from the National Health Laboratory, MoH of Uganda, UVRI, and others.

An excellent series by our team at CIDRAP