TIMELESS trial: Tenecteplase for thrombolysis in a 4.5-to-24-hour window did not improve disability outcomes at 90 days in patients with ischemic stroke who had been chosen on the basis of imaging. Most patients had endovascular thrombectomy. nej.md/3wa2tAR #ISC24

TIMELESS finally published! Imaging-guided TNK within 24 hours of last known well in combination with IAT did not significantly improve functional outcomes at 90 days Surprisingly, though, no increase in sICH! I mean, if it doesn't hurt... 🧠 (jk) nejm.org/doi/full/10.10…

GWTG Stroke study found earlier reversal treatment for brain hemorrhage patients on blood thinners led to better outcomes especially in first 60 minutes or “golden hour." #GWTGResearch #ISC24 spr.ly/6010Vb7KM

A brief summary of the literature on 2-bag fluid methods for DKA. What are you using? #PharmICU

Any pharmacist Medication Safety Officers out there who would be willing to mentor someone new to the med safety world? #TwitteRx #xRx #pharmacists #medicationsafety #medsafety #ismp

🦠 Infectious diseases pharmacist opportunity!l 🦠 My hospital is looking for a full-time ID/AMS pharmacist. Please pass this along! #pharmacy #idsa #infectiousdieseases #idpharmacist #TwitteRx jobs.ardenthealth.com/new-mexico/job…

Check out the details about our upcoming PharmEMergency/AEMP conference happening in May! We want to see all types of EM pharmacists and providers join us and get involved! saem.org/about-saem/aca… Megan Rech, PharmD, MS @GilbertPharmD Lance Ray SAEM @CBthePHARMD Kyle DeWitt

🆕️⚡️⚡️ AJHP Intravenous push antibiotics in ED decrease the time from ordering to the start of administration and result in significant cost savings compared to IV piggyback #IDXposts academic.oup.com/ajhp/advance-a…

Hooray we can continue to not give TNK after 4.5 h nejm.org/doi/full/10.10…

#CPPPLU Highlights: A study in Critical Care found no difference in 28-day mortality with initial adequate combination antibiotic therapy vs. adequate single-drug therapy in critically ill pts with monobacterial gram negative HAP, vHAP, and VAP. #PharmICU loom.ly/I723xZ4

Ketamine drips for sedation can be extremely effective. We just need to sort out/standardize the dosing regimen. This paper evaluates numerous published protocols in an attempt to make sense of it all. 🎩 tip to the authors. eddyjoemd.com/foamed/

Thank you to Madeline Ganter from our fabulous UNC Med Center Pharmacy Residency Programs class who designed our latest #EDpharmacyeducationboard to spread the word about our new High-Dose Nitroglycerin for SCAPE guideline in the ED (adopted from UNC REX!) Go team! #EDRx #twitteRx #pharmacyguideline

Post-hoc analysis of the ULTRA trial shows that early TXA in good grade aSAH patients leads to WORSE functional outcomes than usual care. Outcomes in poor grade with similar. TXA is mostly harmless... but not fully harmless. Use it with care! neurology.org/doi/10.1212/WN…

Andexanet alfa: expensive and harmful? There was no reason to use this drug until now, and nothing changes with the first RCT #FOAMed first10em.com/andexanet-alfa…

New manuscript from EAST multicentered (10 site) AA vs 4PCC in trauma pt's showed no diff in transfusion requirements and maybe shorter ICU LOS w/ 4PCC than AA Decent size and like how they verified pts took a dose w/in 12 hrs of arrival bit.ly/4bG4ogp

🔥Just published 🔥 CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024 #doxyPEP #IDXposts cdc.gov/mmwr/volumes/7…

we have known the rate of thrombotic events with andexanet for a long time. 10% is not unexpected based on previous studies. ANNEXA-4 prelim analysis (2016) - 18% ANNEXA-4 full analysis (2019) - 10% ANNEXA-I (2024) - 10.3% #TwitteRx #FOAMed

How long is too long to be performing CPR in patients who suffer in-hospital cardiac arrest? Every patient and situation is obviously different but it shouldn’t come as a surprise that beyond 30 minutes, things don’t look too good. 🎩 tip to the authors. eddyjoemd.com/foamed/

#JournalWatch CHEST® Journal More data for peripheral vasopressors! This study found that peripheral pressors offered a practical advantage and faster administration but wide practice pattern variation. #critPRN buff.ly/3MjWYo8

🆕️🔥Systematic review: NO evidence that treatment with antibiotics is associated with improved delirium outcomes in older adults with pyuria or bacteriuria and without systemic signs of infection or genitourinary symptoms #idxposts Thanks Ignacio uman agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…