nature Pre-reg works well in highly structured disciplines eg. clinical research, less so in disciplines where serendipity & complexity are more prominent like molcellbio. EMBO Reports we encourage noteworthy null data & refuting data + 'second confirmation' of important claims. try it.

Giulia Monticone Giulia Monticone, Lucio Miele LSU Health Sciences and co-workers describe novel immunomodulatory properties of #adenosine analogs, like #remdesivir, that promote their antiviral activity against #SARSCoV2. -> embopress.org/doi/full/10.10… see also: lsuhsc.edu/news/lsu-healt…

Lynn Kamerlin Caroline Lynn Kamerlin 🇺🇸🇬🇧🇸🇪🇮🇷 ☀️ 🇪🇺🦓: Learning the #language of the host #country has great benefits for academic staff. Read more: embopress.org/doi/full/10.10…

Dr. Marco Flores-Mendez, Naiara Akiz (Naiara Akizu), and their Children's Hospital team studied cellular and molecular mechanisms that lead to selective neuronal vulnerability to purine metabolism imbalance. 🧠 Get the full story in EMBO Reports. 💬 🔗 bit.ly/3WtXJiK

Check out our latest collab. study with the awesome Gaudin lab just out EMBO Reports We used #zebrafish Zebrafish Rock! to probe the contribution of #occludin to #monocyte transmigration. Great job from Amandine Dupas, Vincent Mittelheisser & Naël OSMANI CRBS Inserm Est

Kieran Harvey Harvey Lab and co-workers Peter Mac Cancer Centre Monash Biomedicine Discovery Institute University of Melbourne identify mechanisms by which mesothelioma cells respond to TEAD palmitoylation inhibitors. -> MAPK pathway targeted therapies enhance the anti-tumor activity of TEAD inhibitors. embopress.org/doi/full/10.10…

Read the August issue: embopress.org/toc/14693178/2… The cover shows that cell cycle length governs #heterochromatin reprogramming during #development in non-mammalian #vertebrates. By Hiroto Fukushima Hiroto Fukushima RIKEN and Hiroyuki Takeda UTokyo School of Science. embopress.org/doi/full/10.10…

Muscle regeneration news: researchers from University of Houston identified a key signaling axis for myoblast fusion during muscle repair and growth – which could lead to new therapies for muscle disorders. #OpenAccess via EMBO Reports: embopress.org/doi/full/10.10… #NIAMSfunded

Banning the use of #genetic #data by #insurance companies will therefore allow progress in #medical #research and give greater benefits to #society. Read more here: embopress.org/doi/full/10.10…

Sharon Tooze Sharon Tooze The Crick and co-workers show that WIPI2b recruitment to #phagophores and ATG16L1 binding are regulated by ULK1 #phosphorylation during #autophagy. -> embopress.org/doi/full/10.10…

Going slow is better for fast cycling: Study reveals unique #replication #fork behavior in pluripotent stem cells EMBO Reports phys.org/news/2024-08-f…

Lutz Bornmann Lutz Bornmann on #data #sonification that uses #sound to display large datasets as a possible alternative to data #visualization. -> embopress.org/doi/full/10.10…

🛰️ Satellite cells endow skeletal muscle with the ability to regenerate after a severe injury and this #myogenic potential of satellite cells requires a protein called tripartite motif-containing 28. This discovery was made by the The Hornberger Lab and published recently in

A new review is online! Wei Xie and co-authors explain how #licensors set the stage for the initiation of transcription and its timing, and how #specifiers instruct the activation of specific #genes during zygotic #genome activation (#ZGA) in #mammals. embopress.org/doi/full/10.10…

Gian Paolo Dotto Harvard Medical School on the #anthropology of #war and how to overcome #human killing #instinct. Understanding the factors that make humans go to war may help to overcome our innate tendencies to kill each other. Read more here: -> embopress.org/doi/full/10.10…

Ek-Hoon Jho University of Seoul and co-workers show that retinoic acid-induced protein 14 (RAI14) links mechanical forces to #Hippo #signaling and that the RAI14-Hippo axis plays a pivotal role in gastric #cancer progression. #mechanobiology -> embopress.org/doi/full/10.10…

Nadine Hempel Nadine Hempel and colleagues show that alternative #splice variants of Drp1 limit #mitochondrial fission, improve mitochondrial function and promote #tumorigenicity and #chemoresistance in ovarian #cancer. UPMC Hillman Cancer Center University of Pittsburgh embopress.org/doi/full/10.10…

Unlike the scarce presence in typical eukaryotes, #m1A is prevalent in #dinoflagellate #mRNA. m1A levels correlate with the expression of #metabolism-related genes and respond to #nitrogen #starvation. embopress.org/doi/full/10.10…

Human #pluripotent #stem cell-derived hepatocyte-like cells (HLCs) in culture are a research tool for studying #hepatitis B and D viruses. CD63 is identified as a potential #HDV co-entry factor. Dao Thi Lab CIID_Heidelberg DZIF - Deutsches Zentrum für Infektionsforschung Universitätsklinikum Heidelberg embopress.org/doi/full/10.10…

Activation of an atypical #plant #NLR with an N-terminal deletion initiates #celldeath at the #vacuole. -> embopress.org/doi/full/10.10…