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Orthostatic Hypertension Critical Appraisal of an Overlooked Condition 2020 "The finding suggests that reduction in cardiac preload is the trigger setting off orthostatic hypertension. In some patients, orthostatic hypertension may be triggered by excess venous pooling"

Tip of the day 💡: Bilateral symmetric diffusion restriction in the peri-rolandic cortices can be a strong feature of POLG-related disorders, within the spectrum of mitochondrial depletion syndromes. It was the only clue in this case. No oxymorons there, just a helpful tip 😉.

Tip of the day 💡: Before you call such signal changes nonspecific (or even ganglionic perivascular spaces), think again. They are bilateral and right in the middle of the putamen. Final diagnosis: a mitochondrial disorder, namely IARS2.

Exocytosis in real time?? Bought this cool thing for a dollar from a little kid on my street selling some of his old toys and all I can think of is the secretory pathway

The Trifecta of POTS, HEDS, and MCAS Postural orthostatic tachycardia syndrome, hyper mobile Ehlers-Danlos syndrome, and mast cell activation syndrome are liked by the dysfunction of connective tissue, blood flow, and immune responses.

15. Your phone is destroying your attention span.

Interesting mind-bending thread… But I think hallucination is the wrong term for it. Reality is objective and the brain predicts its perception. The fact that the sensory output lives in the brain doesn’t make existence subjective or terrifying.

May it help interested clinicians and their patients.

Research from last year marked the first documented case of an ape using a plant with scientifically proven medicinal properties to treat a fresh wound. #ScienceMagArchives scim.ag/4j1q751 News from Science

The answer is blowin' in the wind 🎶

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.

Both hES (anti-IL2R+IV methylprednisolone+1 year of prednisone and tacrolimus) and IPS (15 months of tacrolimus) studies used immunosuppression. I wish they’d had an arm with only immunosuppression as a control.

Health advocates applaud MAHA report for calling out chemical harms, but say it falls short via The New Lede | carey gillam ✍️ 📓 #MAHA #pesticides #RFKJR #Parkinsons #glyphosate #PFAS #atrazine thenewlede.org/2025/05/health…

Penguin droppings may be seeding clouds, a new study finds. e360.yale.edu/digest/penguin…

There's only a week left to submit an entry to our MapMySections data challenge! More on the challenge parameters and how to submit: alleninstitute.org/events/mapmyse…

Wow.. the results sound fascinating!! >50% reduction in Apnea-Hypopnea Index at 26 weeks by once daily dosing !! Primary end point ✅

11. Praia das Catedrais - Galicia, Spain

Beware of low antibodies as a complication of b-cell depleters. This is a case report of a 34 year old man on ocrevus for MS who developed catatonia and fever. MRI showed symmetrical thalamic lesions. He had enterovirus encephalitis. IgG was 4.92 g/L neurology.org/doi/10.1212/WN…

MRI findings of genetic diseases often misdiagnosed as MS. A-D LHON B CADASIL. D CANVAS. E Krabbe disease F Cobalamin C disease. G polymerase gamma gene disease. H Alexander J/K CADASIL L Spastic paraplegia 5 with diffuse leukoencephalopathy pubmed.ncbi.nlm.nih.gov/40446704/

Beer drinkers odd ratios for Parkinson’s Disease compared to non-beer drinkers: 0.79 for <1 drink/day, 0.73 for 1–1.99 drinks/day, and 0.86 for 2 or more drinks/day. Is it uric acid? Is it the relaxing social time? Does yeast survive and change the gut?