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A study of 8,276 women w/ endometriosis in UK Biobank found increased odds of depression, anxiety, & eating disorders—and a genetic component, including one locus that affects risk for both endometriosis & depression. In JAMA Network Open: allof-us.org/3WY5Xy2

We finally get to announce that our study "Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma" was published in Nature Communications nature.com/articles/s4146…

Happy to announce that this work has now been published in Genome Medicine! Thanks to the reviewers, whose input greatly helped shape and improve our manuscript. MarioniGroup Catalina Vallejos (catavallejos.bsky.social) Generation Scotland The Lothian Birth Cohorts Check it out here: genomemedicine.biomedcentral.com/articles/10.11…

Great to join Hannah on the Hannah Went podcast. We discuss what DNA methylation is, the importance of the circulating proteome and how these measures were integrated in my PhD to create new markers for disease prediction. Generation Scotland Institute of Genetics and Cancer

Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)

Happy to share my 1st paper, in Biological Psychiatry! We investigated the links between 249 circulating metabolites & Major Depressive Disorder (MDD) in UK Biobank. A thread 🧵 of our main findings:👇

There's something about the Spring that makes you make life-changing decisions! Exciting things ahead. :-)

1/We are excited to finally share our recent work in Cell. We provide guidance for testing for sex differences in the genetic architecture of complex traits. This includes quality control, models, chrX, caveats, limitations, & next directions. sciencedirect.com/science/articl…

Incredibly excited to see what we can learn together Genomics England & MHRAgovuk about how our DNA🧬 affects our response to different medicines💊 Patient need here is so strong (and risks if things go wrong are serious). Here's to good insights! gov.uk/government/new…

Amazing group of humans. :-)

🎉BIG NEWS🎉 Head over to STV and tune in to watch our fantastic volunteers share how important Generation Scotland is & how you can get involved! It’s a doddle! 🏴󠁧󠁢󠁳󠁣󠁴󠁿 👇Alternatively visit our YT to watch anytime! youtube.com/@generationsco… Please share! 🤝📢

Genetic effects on age-at-menopause can change in time! Very excited to share our new age-specific #GWAS on age-at-menopause in #ukbiobank We find age-specificity to be very common leading to novel discoveries and evidence of biological mechanisms 🧵👇 sciencedirect.com/science/articl…

New paper: Blood-based genome-wide DNA methylation correlations across body-fat- and adiposity-related biochemical traits Centre for Genomic and Experimental Medicine Institute of Genetics and Cancer Alesha Hatton @RobertHillary Elena Bernabeu MarioniGroup doi.org/10.1016/j.ajhg…

🚨PhD opportunity!!🚨 Come to do a PhD with me Konrad Rawlik and Kenneth Baillie! We will be looking at shared genetic signals between seemingly distant diseases to find drug repurposing oportunities! 🧬🧬More info: FindAPhD findaphd.com/phds/projectde…

New paper: Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease Centre for Genomic and Experimental Medicine Institute of Genetics and Cancer Usher Institute EdinburghCRF 💙 MarioniGroup Lee Murphy Andrew McIntosh Generation Scotland Aleksandra Chybowska Danni Gadd Elena Bernabeu Read more here: doi.org/10.1161/circge…

Last 1st author work from my post-doc with MarioniGroup now out on medRxiv!

The @I2SysBio institute (Valencia, Spain) is seeking #postdocs in #computationalBiology to participate in the upcoming Digital Talent Attraction program by CSIC: 4-year appointments with a competitive salary in a great institute. ISCB Student Council SEBiBC INB / ELIXIR-ES ELIXIR Europe

A genome-wide association study captures how a common genetic variant might be linked with disease. In the latest bioinformatics blog, Elena Bernabeu talks through variant-gene mapping, sharing how her team approaches the task. ow.ly/lqNq50SOTKe #bioinformatics