Memorial Sloan Kettering Cancer Center & the Tri-I community let's continue celebrating MSKPDA this #NPAW2022! Join us Thursday, 9/22, 10am-5pm for our Annual #MSKPostdocs Research Symposium. The day will include 12 oral talks, a poster session (yes! posters are back!) & a keynote by @nogaleslab.

An👩‍🎨 as much as a👩‍🔬. For #NPAW2022 meet #MSKPostdoc Eleonore Toufektchan from the @Maciejowskilab. Eleonore Toufektchan is studying how the protein TREX1 helps cancer cells resist immune checkpoint blockade therapy & anti-tumor immunity.🇫🇷

And here are some of the embroideries and sculptures Eleonore Toufektchan have done! Thanks for sharing your artistic side with us! For more of her work, check Eleonore's instagram account: @eleonore_stitches

Thank you for highlighting my work as a postdoc for #NPAW2022 !!!

One of the best things about lab is working with great scientists like Eleonore Toufektchan!

Eleonore Toufektchan works on elucidating how TREX1 activity facilitates chromosomally unstable cancer cells to escape from anti-tumor immunity and immune checkpoint blockade therapies. @Maciejowskilab

📆 Les 15, 16 et 17 mai prochains, l'Institut Curie vous donne rendez-vous au cœur de Paris dans un cadre historique et prestigieux, pour la 1ère édition de son Symposium International "From Basic Science to Cancer Research". Pour en savoir plus ↘️ curie.fr/actualite/even…

Congratulations to Eleonore Toufektchan and all co-authors on our new study showing how TREX1 guards against anti tumor immunity by degrading cytosolic DNA to limit cGAS-STING! Great collaboration with the Samuel Bakhoum lab.

Come and work with us at Penn in Philadelphia as a research specialist A (lab tech). Great opportunity to hone your molecular biology research skills in preparation for grad school in a strong lab. Hands on research experience a benefit, willingness to work with mice a must. #job

As part of the Immunity session at the 1st International Symposium of Institut Curie, Eleonore Toufektchan, postdoc at Memorial Sloan Kettering Cancer Center will discuss the role of intra-tumoral TREX1 induction in immune evasion. 📅 May 15 > 17, 2024 📍 Maison de la Chimie, Paris ➡️ curiesymposium.fr/registration/

A lot of fun to highlight great work from Giuseppe Leuzzi and Alberto Ciccia et al showing how the the DNA translocase SMARCAL1 dampens immune responses against tumor cells through two distinct mechanisms. Together with Eleonore Toufektchan in Molecular Cell. authors.elsevier.com/a/1ijJ1_Oylrla…

Happy Birthday, Rosalind Franklin! We celebrate her work and influence in science. Thanks to her, we have the historic Photo 51, which revealed that DNA has a double-helical structure!

Rosalind Franklin was already a renowned structural biologist when on July 25, 1955 - her 35th birthday - she wrote to her dept. chair requesting a well-deserved raise. The arguments would be familiar to any academic today!

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination bit.ly/4fKCvpV

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

Special thanks to our great collaborators John Maciejowski, Eleonore Toufektchan and Yanyang Chen from MSKCC, as well as Grégoire Cullot, Alessandra Albertelli and my postdoctoral advisor, Jacob Corn Jacob Corn for their amazing help in making this publication possible.

Check out this amazing work by Erman KARASU ! Thank you for this opportunity to work on yet another surprising role for TREX1: mediating gene editing efficiency. Congrats!