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🆕 NLRP3 #inflammasome activation in sensory neurons promotes chronic inflammatory & #osteoarthritis pain Patrícia Silva Santos Ribeiro Niels Eijkelkamp et al. indicate that targeting NLRP3 may open doors to improved #Chronicpain management 👉bit.ly/3Qi2xVx @CTI_umcutrecht @IenI_umcutrecht

Great work Geoffrey!

We should also chat. Curious to known how you think IL10 signalling and MiTo transfer may be linked to each other to pain resolution (or not).

New work by Hanneke Willemen in @cellrepmed. Great team effort! Mitochondrial/metabolic disturbances in sensory neurons predispose to failing resolution of inflammatory #pain. NR supplementation alleviates persistent inflammatory pain. Center for Translational Immunology cell.com/cell-reports-m…

Research at Center for Translational Immunology in Cell Reports Medicine has found that mitochondrial/metabolic disturbances in sensory neurons predispose to failing resolution of inflammatory #pain. Nicotinamide riboside supplementation may alleviate persistent inflammatory pain 👉edu.nl/mg474

A nice coverage of our recent publication in Cell Reports Medicine by Grace Wade in New Scientist. newscientist.com/article/240140…

WORK!!! At Center for Translational Immunology we offer a PhD position to investigate the pathophysiological mechanisms underlying myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and help building a Dutch pediatric ME/CFS cohort. More info here: edu.nl/rcrch (Closes Dec. 14)

New work by Christian Martin in BrainBehavImm! Earlier we identified that dorsal root ganglia macrophages maintain pain in osteoarthritis. But what drives the accumulation and their pro-algesic function? CXCL11 & Mysostatin! Center for Translational Immunology. Read more at: sciencedirect.com/science/articl…

.Harald Lund, Matt Hunt, Zerina Kurtovic, Camilla Svensson et al. provide a molecular explanation for the permeability of the blood–DRG barrier and identify an unappreciated role of #macrophages as integral components of the DRG-neurovascular unit. hubs.ly/Q02dx2Mg0 #InnateImmunity

From acute to chronic: #NLRP3 inflammasome's role in #pain evolution Patrícia Silva Santos Ribeiro Niels Eijkelkamp et al. report intriguing findings on the role of mitochondrial dysfunction & NLRP3 #inflammasome activation in the transition from acute to persistent pain 👉bit.ly/48JknIs

🎉We're proud to announce The Netherlands National Cohort and Biobank Consortia – an eight-year collaboration of Dutch research institutes, medical centers & patient organizations dedicated to the study of ME/CFS➡️nmcb.eu

#ChronicPain in rheumatic diseases: #NLRP3 inflammasome takes centre stage This study from Patrícia Silva Santos Ribeiro Niels Eijkelkamp et al. explores the link between sensory neuron #inflammasome activation & persistent inflammatory & #osteoarthritis pain Read here: bit.ly/48JknIs

At Center for Translational Immunology we offer a PhD position within the EU-funded Innovative Training Network BonePain3 (bonepain.eu). Are you interested in neuro-immunology and research on mechanisms and treatment of osteoarthritis pain, apply here: edu.nl/t9k4y

We have 2 new PhD student vancancies funded by the EU! You will be part of the BonepainIII consortium (bonepain.eu). Enthousiastic to work on Bonepain in our group and happy to move to the Netherlands: check it out! werkenbijumcutrecht.nl/vacatures/wete… werkenbijumcutrecht.nl/vacatures/wete…

Are you a LAB TECHNICIAN interested in performing in-depth molecular research on a mitochondrial regulator of pain to understand how this mitochondrial protein controls pain and to aid in the design of compounds to treat chronic pain? Then apply here: edu.nl/gpttx

🗓️📣 Kom jij het NMCB team versterken als verpleegkundige? Solliciteren kan nog t/m 30 maart! ➡️ We zoeken een ervaren BIG-geregistreerde verpleegkundige om het includeren van patiënten in het cohort en de biobank uit te voeren en te coördineren. 👉 werkenbij.amsterdamumc.org/nl/vacatures/z…

Nature research paper: CGRP sensory neurons promote tissue healing via neutrophils and macrophages go.nature.com/43DyiPe

A strong indication for #autoimmunity in #longcovid: transfer of antibodies of patients induces symptoms in mice. Check out our latest preprint bioRxiv: biorxiv.org/content/10.110… 1/11

Preprint of supercool #teamscience UMC Utrecht Amsterdam UMC. With Jeroen den Dunnen Hung-Jen Chen (Oliver), MD. PhD. NerD. Hanneke Willemen and many more: evidence autoimmunity may cause part of #longcovid symptoms. But still much more figure out! Big 👍 for funders: Stichting Long COVID ZonMw biorxiv.org/content/10.110…

Nice coverage of our preprint by @carissaCWWong @nature that brings more context of the story nature.com/articles/d4158…