Evaluating different deconvolution algorithms today. Behold the power of Richardson-Lucy!

In the latest issue! Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors dlvr.it/TLccts

Top 5 advances in medicine this week (🧵) 1. Adults can produce new neurons, after all A decades-old problem is whether adults can produce new neurons. It’s been proven in mice – but never in humans This is the stunning discovery that the full pathway of new neurons - from the

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment nature.com/articles/s4159…

Nucleosome spacing can fine-tune higher-order chromatin assembly: nature.com/articles/s4146…

How short peptides disassemble tau fibrils in Alzheimer’s disease: nature.com/articles/s4158…

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe

Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center including TAMEST Member Eric N. Olson, Ph.D., blocked the symptoms of a rare smooth muscle disease before they developed. Read More: buff.ly/cR43PEE

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior. Congratulations Jing! Happy to have contributed in a small way to this interesting work! nature.com/articles/s4146…

Architecture and Function of Holocentric CENP-A-Independent Kinetochores biorxiv.org/content/10.110… #biorxiv_cellbio

Our paper is now online. We started with glycogen storage disease XV, aiming to understand how GYG1 mutations cause glycogen accumulation and cardiomyopathy. Unexpectedly, we uncovered a fundamental role for GYG isoforms in glycogen particle assembly. nature.com/articles/s4146…

Now online! Regulation of inflammatory responses by pH-dependent transcriptional condensates dlvr.it/TM0Mvr

Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses & enables rational

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…

Silas Miller is a PhD student in Cellular and Molecular Biology from Seattle, Washington. As a member of the Raman Lab, Silas studies a type of protein that pumps antibiotics out of bacteria and makes them drug resistant, called an efflux pump. grad.wisc.edu/2025/07/10/sil…

How do cells organize six feet of DNA in a tiny nucleus? Huabin Zhou, Ph.D., a postdoctoral fellow in the Rosen Lab, is uncovering the answer and just earned the 2025 Brown-Goldstein Award for his work on chromatin structure and biomolecular condensates. bit.ly/4lGmxzm

Excited to share our new preprint on bioRxiv from our great team @EMBL! biorxiv.org/content/10.110… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus

A new paper from Alice Ting reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces nature.com/articles/s4158…

My penultimate PhD project is out in Nature Chemical Biology! We engineered LaccID, a cell surface-specific enzyme for proximity labeling and EM. Derived from an ancestral laccase, it performs the same chemistry as APEX2 but using O2 instead of H2O2. nature.com/articles/s4158…

Excited to share our work out in Current Biology today! We find that NuMA acts as a spindle "glue" - independent of its partner dynein. Congrats to student Nathan Cho who led the work, and thanks to Merve, Aryan and Ahmet Yildiz for in vitro help. cell.com/current-biolog…