A closer look at a dying neuron accumulating misfolded tau protein! Markers: 🔵Dapi🟣NeuN🟡Phospho Tau serine 422. ZEISS Microscopy #neuroscience

Stroke blood vessel localization and corresponding territories on MRI. Credits: Jeremy Heit, MD, PhD #MedTwitter

Curious about a showdown between 10x Genomics' Xenium & @nanostringtech's CosMx platforms ran in my lab and on sequential sections? Join us on Oct 25 at 4:30 pm AEDT #ozsinglecell23! #SingleCellSpatial #MetricsMatter #DataSpeaksTheTruth #More2Come #CutAboveTheRest

I celebrate when: I make stuff fluoresce, My mice follow a paradigm, My code works, I have successfully cut tissue, I understand a dense paper, I know the writing needs more flow, I can explain and when I make it through the day without threatening to leave and join the Navy 😬

What if we kissed while head fixed on the polystyrene ball treadmill

What's the biggest difference between a neuron from a young vs. an aged primate? It is not the length of the axon and dendrites, but the number of spines available to make contact and connections with other surrounding neurons! 3D recon. made with Imaris 3D/4D Imaging #neuroscience

🩸🧠CAA and Alzheimer's disease spectrum (CAA=Cerebral Amyloid Angiopathy) 📒 Notes: -Most patients with AD have mild/moderate CAA and not the advanced "bleeding" CAA subtype. -AD and CAA have different dominant Aβ species: 🧶AD - Aβ42 predominant (less soluble, stick together

Pleased to post our Nature Protocols pub profiling human vasculature using transcriptomics and organoids 🧬🧠🧫. rdcu.be/dtHaO Building off previous work in 🐭brain, we describe human specific procedures for #flowcytometry #neurovascular #organoids & #transcriptomics

Donna Wilcock, PhD, received a $3.36 million grant from NINDS to study why edema and microhemorrhages occur in the brains of some people who receive Alzheimer’s therapies: bit.ly/3uxDK96

It is an honor to receive the Early-Career Scientist Award by The Rainwater Charitable Foundation. Grateful to work with a great team Pablo Martínez C. Nur Jury Garfe Henika Patel Enrique Chimal Jonathan Martínez Muriel Mardones and thankful to be part of @NeurosciStark IU School of Medicine

Congratulations to lead author Michelle Cahill, Max Collard, @vincenttse, and team for this work on how astrocytes respond to glutamate and GABA, the two major neurotransmitters in the brain. 🎉 nature.com/articles/s4158…

🧠MRI lesions ~ ⭕️Small Vessel Disease type Cerebral amyloid angiopathy vs. Hypertensive arteriopathy #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #stroke #MedStudentTwitter #FOAMncc #MedTwitter #amyloidangiopathy #FOAMncc #neuroscience #brain #Alzheimers #Alzheimer

Excited to be back at #AAIC24! 💜looking forward to lots of great science.. 🧠Come check out posters and talks from Lasagna-Reeves Lab members during this week! Nur Jury Garfe Pablo Martínez C. Enrique Chimal Muriel Mardones Alzheimer's Association @NeurosciStark

Interested on spatial transcriptomics and CAA and the differential role of microenvironment in #Alzheimer's? Please stop by my poster at #AAIC24 Alzheimer's Association on Monday-155 (3:30-4:30). Make sure to check all the great work from Lasagna-Reeves Lab and @NeurosciStark. #goteamstark

Yesterday, to understand the microenvironment, I became an amyloid aggregate at a vasculature. Come learn about microenvironment differences in #AD and #CAA. Stop by my poster at #AAIC24 Alzheimer's Association on Monday-155 (3:30-4:30). Lasagna-Reeves Lab @NeurosciStark. #goteamstark

Day 3 at #AAIC24. The day begun full of energy with a 5K run (sponsored by Novo Nordisk). Got third place overall 🥉. The rest will for sure be full of amazing science and friends! Following Lasagna-Reeves Lab favorite Rocky pose advice. @NeurosciStark

If you’re around till the end of #AAIC24, and interested to know how Bassoon- a #synaptic protein- can trigger #tau aggregation, #neuroinflammation and drive #neurodegeneration? 🧠 Come listen to my talk tomorrow at 9:15 in Room 118-ABC! Lasagna-Reeves Lab Alzheimer's Association

Resilience against AD neuropathology might rely on the amyloid plaque microenvironment. Want to learn more? Check out our paper in Acta Neuropathologica! Excellent job Nur Jury Garfe Pablo Martínez C. Enrique Chimal in the lab and our collabs Jungsu Kim Hande Karahan link.springer.com/article/10.100…

Checkout the new publication!, it is a fantastic collaborative work lead by Nur Jury Garfe !

🧠 Check out our new paper in Alzheimer's & Dementia Journals exploring how tau depletion improves vascular amyloid‐related deficits in a mouse model of CAA Thanks to Alzheimer's Association The Rainwater Charitable Foundation NIH Funding for supporting this work! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…