On AIRR 15: Germline databases or adventures into the allelic underworld with Dr. Corey Watson and Dr. William Lees podbean.com/ew/pb-nvt5d-14…

Looking to the future of antibody genetics: resolving the roles of immunoglobulin diversity in gene regulation, function, and immunity | Genes & Immunity nature.com/articles/s4143…

Affinity-optimizing enhancer variants disrupt development | Nature nature.com/articles/s4158…

Improve your BCR sequencing analysis with refined IG germline gene reference sets: frontiersin.org/articles/10.33… airr_community

The new validated AIRR-C human immunoglobulin germline gene reference set for better annotation of #antibody sequences. You should consider to use it for your #AIRRseq studies. Also available for use in IgBlast (ncbi.nlm.nih.gov/igblast/). frontiersin.org/journals/immun…

frontiersin.org/journals/immun…

I have written an 'intermediate programming' course which is aimed at helping improve programming skills of bioinformatics/computational biology graduate students and postdocs. The notes are self-contained and are freely available: iprogramming.bacpop.org

Addressing technical pitfalls in pursuit of molecular factors that mediate immunoglobulin gene regulation biorxiv.org/cgi/content/sh… #biorxiv_genomic

De novo detection of somatic mutations in high-throughput single-cell profiling data sets nature.com/articles/s4158…

A briliant detective story moving from genomics > funtional genomics > theraphy. Showing how the intergenic haplotype on chr21q22 (which is linked to inflammatory dieases) regulates the expression of ETS2, a master regulator of macrophage inflammation. nature.com/articles/s4158…

Eric Engelbrecht showing us that we have much to discover in the human IGK locus! Gene conversions, novel inversions, SVs, SNVs, genes and alleles...oh my! rdcu.be/dJ8mL

nature.com/articles/s4143…

Long-read profiling tools will ultimately be needed to fully resolve functional impacts of IGH germline variation on expressed Ab repertoires The Journal of Immunology Eric Engelbrecht doi.org/10.4049/jimmun…

More work from Eric Engelbrecht and Oscar L Rodriguez on the value of long-reads for investigating the regulation of V(D)J recombination doi.org/10.4049/jimmun…

SIngle cell level Genotyping Using scRna Data (SIGURD) biorxiv.org/cgi/content/sh… #bioRxiv

A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy Nature Biotechnology Michal Bassani-Sternberg nature.com/articles/s4158… nature.com/articles/s4158…

A new paper, led by Kerry Mullan from Pieter Meysman’s (Pieter Meysman) group, advocates for a TCR-centric approach to analyzing scRNA data from T cells. One highlight is the identification of melanoma- and colitis-specific TCR clusters. | Science Advances doi.org/10.1126/sciadv…

Our paper on single-cell splicing QTL is now published as a cover article in Nature Genetics. nature.com/articles/s4158… Congratulations to co-first authors Tian Chi, Yihan, and Yuntian Zhang! Huge thanks to AIDA leaders Shyam Prabhakar Lab , Woong-Yang, JayShin and Kian Hong!

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: Dana-Farber News Dana-Farber Division of Population Sciences Boston Children's Broad Institute Science Magazine science.org/doi/10.1126/sc…