When the lab veteran agrees to teach you how to run a western blot

Announcing npj Dementia, an exciting new Nature Portfolio journal, led by EIC Dr Jen Yokoyama. nature.com/npjdementia/

I am thrilled to announce the launch of npj Dementia, for which I will be serving as the Editor-in-Chief. npj Dementia will be fully-open access and publish research that advances the field towards effective disease interventions. (1/3)

🚀 Excited for Jennifer Yokoyama to serve as Editor-in-Chief for npj Journals! #DementiaResearch #OpenAccess #cwowleads

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

Immortal quote from the amazing geneticist Gerry Fink… “Just because it’s in Nature… … doesn’t necessarily mean it’s wrong!”

Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS  #multiplesclerosis #Tcells #EBV 🧵1/ biorxiv.org/content/10.110…

A neurologist in Colombia, he worked with the world’s largest extended family with Alzheimer’s and helped fuel research to prevent or delay dementia symptoms. nyti.ms/3MGKozi

HHMI Investigator Zhijian "James" Chen of UT Southwestern Medical Center has been named the 2024 Albert Lasker Basic Medical Research Award winner for his discovery of the DNA-sensing cGAS enzyme, which triggers immune & inflammatory responses. 👏 👉 hhmi.news/47wJnn2

I learned something new today!

Learn about the intriguing connections between neurodegenerative & neuropsychiatric diseases 🪢 via alterations in interferon signaling! 🧠 Daniel Sirkis Alexis Oddi 💻 Caroline Warly Solsberg UCSF MAC DataTecnica FTDcwow Global Brain Health Institute #WomenInSTEM frontiersin.org/journals/psych…

I enjoyed leading this effort to highlight recent advances in understanding interferon pathway dysregulation in neurodegenerative disease, including new work by our group. We also discuss cognitive and behavioral changes related to IFN and its relevance in psychiatric disease.

Circulatory proteins shape microglia state and boost phagocytosis!!!!! biorxiv.org/content/10.110…

Continuing with #crossreactivity and #TCR Another paper that I #love We simply #cant #afford to have "#holes" in the #repertoire. Virus-Specific CD4 Memory-Phenotype T Cells Are Abundant in Unexposed... sciencedirect.com/science/articl…

For the first time in 114 years, biologists from the Oregon Department of Fish and Wildlife have observed a fall-run Chinook salmon returning to spawn in the Klamath Basin in Oregon, after dam removal.

Having worked on mechanisms of unconventional synuclein secretion, this paper looks awesome and the data compelling. However--not having read the full text--I am left with the following dispiriting impression: - Arc function = bad outcome - lack of Arc function = bad outcome

Holy moly. In some individuals, p-tau181 is >300-fold higher in cervical lymph nodes than plasma. Seems like this could be a reasonable location to predict exposure of T cells to tau-derived peptides.

New paper out📢! Toxic effects of IFN-I in humans has been suggested in patients with rare monogenic autoinflammatory diseases (SAVI, CANDLE, AGS) where IFN-I are elevated. In the absence of specific inhibitors, their causal role has been difficult to prove. We now report benefit

Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. Jonathan Kipnis 💔🎗️ nature.com/articles/s4158…

Check out our new preprint showing our ability to use epigenetic age measured from blood to predict AD progression & cortical atrophy! ⁦Daniel Sirkis⁩ ⁦UCSF Imaging⁩ ⁦UCSF MAC⁩ ⁦Hernando Santamaría-García⁩ ⁦Agustin Ibañez⁩ ⁦⁦Cornell University⁩ researchsquare.com/article/rs-527…