Excited to share our latest work in microscope development from Prakash Lab, with Deepak Krishnamurthy, Ethan Li, Pranav Vyas, Nibha Akireddy, Chew Chai and PrakashLab: biorxiv.org/content/10.110…. (1/n)

We combined de novo designed isoform-specific minibinders with novel oligomeric scaffolds to modulate FGFR signaling. The FGF-mimetics were used to program cellular decision making and we found that the FGFRc-isoform is relevant in vascular differentiation for arterial cell fate.

Wow 🤩

I'm excited to announce Kapil Bharti's selection as Scientific Director for the NEI. Kapil is a superb basic/translational scientist - he'll lead >20 labs, 6 core facilities, & 300 staff in our Intramural Research Program. bit.ly/3LaGO0o @KapilkBharti123

Exciting news! Cellino's #ARPAHDash idea for scalable personalized #celltherapies made it to Round 1 voting at the ARPA-H challenge. Please #vote for "Your Cells, Your Cure" by Willie Reaves in the Scalable Solutions category at plyplx.us/brackets. Voting ends tmrw! 🗳️

Awesome work from Harry McNamara capturing snapshots of signaling in living cells to get to the bottom of the symmetry breaking mystery of gastruloids under uniform conditions!

Many happy returns to our Sir John Gurdon on his 90th birthday 🎉

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in nature nature.com/articles/s4158…. Thread 👇(1/N)

Extremely happy to share the first manuscript of the lab! 🥳🥳🥳In this paper, we have looked at the coupling between delamination and differentiation at gastrulation. If you are interested in pluripotency, gastrulation, and mouse embryos keep reading! sciencedirect.com/science/articl…

We’re very excited to share the first preprint from my lab along with Harry McNamara, @BillZJia, Adam Cohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development. biorxiv.org/content/10.110…

Congratulations Alexander Schier of Biozentrum, University of Basel, newly inducted #NASmember! #NAS161 #biology

This being a collaboration with the Daniel J. Cohen (CohenLab at Princeton) lab, we just had to see how tissues would respond to local EGFR stimuli at macroscopic scales. Here is a 6 mm diameter tissue with a 1 mm light pattern. Cell rearrangements propagate hundreds of microns from the light boundary!

Great paper with intuitive metrics for characterizing self-organization! Interested to see how real developmental trajectories (from pre-patterned to not) map to their landscapes

Deep learning is not fundamentally antagonistic to understanding mechanism, even though that is the general perception based on most common high profile use cases. 1/

After precisely 4 years of grad school, I'm excited to share that the FIRST PEER REVIEWED PAPER FROM MY PHD HAS LANDED! cell.com/cell-systems/f… Indulge me in some back-story. 🧵

Happy to have this finally on BioRxiv! Oscillations matter! 😎 Also check out the cool techniques #singlecelltracking #microfluidics

I’m thrilled to announce: at JURA Bio, Inc. we’ve constructed a new kind of generative protein model, which allows us to manufacture its generated designs in the real world at petascale. Paper: static1.squarespace.com/static/66db3a5… Blog: jura.bio/blog/variation…

This year’s #NobelPrize laureate in physics John Hopfield created an associative memory that can store and reconstruct images and other types of patterns in data. The Hopfield network can store patterns and has a method for recreating them. When the network is given an

Check out this new paper from Rumya engineering nucleases to be less immunogenic! Awesome interdisciplinary work, going from in vitro, to in silico, to in vivo 🧫💻🐁