Matrix disequilibrium in Alzheimer's disease and conditions that increase Alzheimer's disease risk pubmed.ncbi.nlm.nih.gov/37304012/

AI Unlocks Mysteries of Brain Fluid Flow: A Leap Forward in Alzheimer’s Research Researchers used AI to measure brain fluid flow, a key factor in diseases like Alzheimer's. This innovative AI-based technique offers new insights into the brain's fluid dynamics, opening the door

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase

Dynamic regulation of the extracellular matrix in reward memory processes: a question of time pubmed.ncbi.nlm.nih.gov/37396928/

Our atlas of #perineuronalnets and #parvalbumin cells in over 600 regions of the mouse brain is online on #CellReports ! We also launched a web app to explore the data at pnnatlas.sns.it #BrainResearch #Neuroscience Scuola Normale Allen Institute FENS

ECM proteoglycans support aged hippocampus networks in rats pubmed.ncbi.nlm.nih.gov/37572527/

I'm excited to share this recent publication linking extracellular matrix status to hippocampus-dependent cognition in aged rats. This work is the product of a pilot grant from the Collaboratory on Research Definitions of Reserve and Resilience. sciencedirect.com/science/articl…

A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA receptors pubmed.ncbi.nlm.nih.gov/37591201/

👉 Welcome to Day 3 of #SfN23!! The early bird catches the aging 🐭! We visited Daniel Gray poster "Reward-based foraging behavior alters microglia-hyaluronan interactions in the ventral tegmental area during healthy brain aging" (1/2). Go see it!!

New preprint with aspects of my postdoctoral work with De Biase Lab. This work links microglial and extracellular matrix aging phenotypes with synapse status in mesolimbic dopamine pathways. biorxiv.org/content/10.110…

It was an honor to be a part of Pint of Science US and share a few strategies for healthy brain aging at Firestone Walker brewery. What a wonderful outreach program!

Introducing Daniel Gray (Daniel Gray) as one of our 2024 Early Career Scholars! Daniel is a postdoctoral fellow at UCLA David Geffen School of Medicine at UCLA studying cognitive decline and resilience. Congrats, Daniel! #AGEScholars #AGETC #AGE2024

Changes in the Extracellular Matrix with Aging: A Larger Role in Alzheimer's Disease pubmed.ncbi.nlm.nih.gov/38811161/

Our new study on the role of ECM in synaptic phagocytosis by microglia is online: onlinelibrary.wiley.com/doi/10.1002/gl…

Wow! I don't see this getting much discussion on X. This work is challenging previous cherished work show microglial contributions to visual circuitry. Wonder your thoughts/critiques of it. nature.com/articles/s4159…

Big Nature paper this week on improved lifespan (in mice!) using an antibody to block IL11 Old mice without IL11 even look healthier 🧵

Check our newest pub using legacy macaque brain tissue from the Barnes lab (U of Arizona): A 3D reconstruction of the macaque locus coeruleus using MRI and histological alignment strategies I am grateful we continue to learn from these precious animals. sciencedirect.com/science/articl…

Great work! This will be an important paper for the glial-matrix field. nature.com/articles/s4159…

It is incredibly humbling to think of all the amazing mentors, colleagues, and trainees it took to reach this career milestone. You are as good as your team, and I have a great one! @SCAgingBrain Simons Foundation simonsfoundation.org/2024/08/15/sim…

Share widely! This year, we're looking for scientists whose research vision for their future lab contributes to the mission the @SFARIorg or @SCAgingBrain. Hear directly from the fellows - short clip below with a link to the full video featuring 3 awardees! #FundingOpportunity