In vivo CAR-T cell therapy nature.com/articles/s4157… rdcu.be/eI7zH This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies

Optimizing CAR T cell therapy for solid tumours: a clinical perspective Why has the success achieved with CAR T-cell therapy in hematologic malignancies not been replicated in solid tumors? A great review👇 nature.com/articles/s4157…

Nice review here in NatureRevClinOncol The tumour microenvironment in #PancreaticCancer — new clinical challenges, but more opportunities nature.com/articles/s4157… By Lei Zheng Mays Cancer Center at UT Health San Antonio Sidney Kimmel Comprehensive Cancer Center

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body. The Nobel Prize laureates

Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells nobelprize.org/prizes/medicin… For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review nature.com/articles/s4157… rdcu.be/eJHU8

Targeting organelle function in T cells for cancer immunotherapy bit.ly/439dEak

Happy to share my lab’s work out today in Cancer Cell demonstrating that multiple myeloma relapses after CAR T therapy frequently express low BCMA levels. We develop novel SEMA4A-directed CAR T cells eradicating MM, especially under BCMA low conditions. authors.elsevier.com/a/1lvYf_YwcvnX…

Review Cell Reports Medicine Yvette van Kooyk 🇳🇱 Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation cell.com/cell-reports-m…

Microenvironmental regulation of solid tumour resistance to CAR T cell therapy bit.ly/47bokGU

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors go.nature.com/3Jc62gv

A lactate–acetate interaction between macrophages and cancer cells drives metastasis go.nature.com/3JdFFaa

Online Now: TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors dlvr.it/TNnYb6

Parity and breastfeeding reduce the risk of breast cancer via accumulation of resident memory CD8 T cells in breast tissue nature Sherene Loi, MD Mackay Lab Peter Mac Cancer Centre University of Melbourne Balaji Virassamy Peter Savas nature.com/articles/s4158… 🇦🇺

Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment Immunity Katharina Imkeller 🇩🇪 cell.com/immunity/fullt…

Happy to announce publication of our new paper: CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy | Nature Biomedical Engineering Congratulations, Angel and Team!!! nature.com/articles/s4155…

💥 Exciting findings from MD Anderson Cancer Center! mRNA vaccines may do more than prevent infections — they could also enhance cancer immunotherapy. A new study found that patients with NSCLC and metastatic melanoma who received a SARS-CoV-2 mRNA vaccine within 100 days of

Honey, I ate the kids: how hunger and hormones make mice aggressive nature nature.com/articles/d4158… nature.com/articles/s4158…

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - clinically available mRNA vaccines targeting non-tumour-related antigens are potent immune modulators capable of sensitizing tumours to ICIs nature.com/articles/s4158… nature

Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence nature.com/articles/s4155… Nature Biomedical Engineering