Mechanisms of adrenal insufficiency with tuberculosis endotext.org

Pathogenesis of typhoid fever following pathogen ingestion doi.org/10.1038/s41572…

⭐5 blindspots when tackling the global threat of antimicrobial resistance (AMR) 1. Low and middle-income countries (LMICs) 2. Primary care 3. Informal health-care providers 4. Antibiotic abuse in livestock animals 5. Diagnostics e.g. POC tests doi.org/10.1016/j.lanm…

Insisting to "complete the course of antibiotics" even after making alternative diagnosis

Another new organism unlocked 🍄 And found that it's being covered in the ECMM guideline for rare yeast infections The Lancet Infectious Diseases doi.org/10.1016/S1473-…

Clinical features suggesting community-acquired MRSA pneumonia ⭐Panton-Valentine leukocidin, a toxin that destroys polymorphonuclear leukocyte, is a major virulence factor of CA-MRSA ⭐Linezolid is the preferred treatment as it inhibits toxin production doi.org/10.1056/NEJMcp…

Shiga toxin–producing E.coli (STEC) infection and microangiopathy including hemolytic-uremic syndrome (HUS) Risk factors for HUS: ➡️STEC with Shiga toxin 2 (e.g. E.coli O157) ➡️Age <5 ➡️Antibiotic use (⭐avoid in immunocompetent with bloody diarrhoea) doi.org/10.1056/NEJMra…

TMPSMX may⬆️serum digoxin level by inhibiting its renal secretion ⭐avoid combo(or⬇️digoxin dose) This population-based cohort study shows the 30d risk of 🏥encounter from digoxin toxicity was ~6X higher in elderly co-prescribed TMPSMX vs amoxicillin doi.org/10.1002/phar.2…

Anti-TB drug resistance genes and mechanisms ⭐>95% of rifampicin-resistant strains have mutations of the rpoB gene, making it an optimal target for detection of rifampicin resistance doi.org/10.1080/147872…

Mechanisms through which natural disasters trigger fungal outbreaks doi.org/10.1016/S2666-…

Diagnostic algorithm in 2024 to differentiate intestinal tuberculosis from Crohn's disease doi.org/10.1097/QCO.00… (FCP = fecal calprotectin)

【Viruses and human cancers】 Let's note there are 8 viruses that cause human cancers! Level: Intermediate Importance: ★★★★★ #IDMedEd #IDFellow #Cancer MD Anderson Cancer Center Harrys Torres

Different types of circulatory shock doi.org/10.1056/NEJMra…

Emerging mechanisms of resistance in Gram-positive and Gram-negative pathogens doi.org/10.1038/s41579…

Antibiotics were associated with 28% of SJS/TEN cases described worldwide according to this systematic review and meta-analysis Sulfonamides are the leading culprit, associated with 32% of cases doi.org/10.1001/jamade…

Dual β-lactam therapy works for M.abscessus Is it useful for M.avium complex (MAC) as well? Statistically significant ⬇️ of meropenem MIC was noted when it's combined with ceftaroline(CPT), cefdinir(CDR) and cefuroxime(CXM), especially with CPT and CDR doi.org/10.1093/jacamr…

An algorithm for the diagnosis of VAP (CPIS = Clinical Pulmonary Infection Score) doi.org/10.1038/s41467…

💥So far 40 cases (2 fatal ☠️) of invasive group B strep infection caused by ST283 have been identified throughout Hong Kong 🇭🇰 over past 1 month Majority had contacted with or handled raw freshwater fish before symptom onset scmp.com/news/hong-kong…

Top 10 deadliest pathogen–drug combinations in different regions in 2021, by burden attributable to AMR doi.org/10.1016/S0140-…

Simplifying hand hygiene into 3 steps (vs the usual 6 steps recommended by WHO) results in: ⭐Higher compliance rate ⭐Shorter time for completion ⭐Similar effectiveness (reduction in bacteria colony counts, HAI) 👏🏻👏🏻👏🏻 doi.org/10.1093/ofid/o…