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Great talk from Nathan Fiore on targeting antibodies to alleviate neuropathic pain in mice at the NeuPSIG symposium IASP

Nerve injury promotes IgG secretion from B cells, activating Fc gamma receptors in the dorsal root ganglia and spinal cord, leading to pain in mice Science Translational Medicine Peter Grace, Ph.D. Michael Lacagnina science.org/doi/10.1126/sc…

I had the privilege of working with the absolute dream-team of supervisors and collaborators: Camilla Svensson, Terry Walters, Prof Mark Hutchinson, Dr. Cobi Heijnen, Ted Price director of CAPS at UT Dallas, and the person who made it all happen, Peter Grace, Ph.D.. Thank you all so much!

Thank you Michael Lacagnina for bringing us into this amazing project! Great new paper in Science Translational Medicine science.org/doi/10.1126/sc… And we got the cover! UT Dallas Research and Innovation Center for Advanced Pain Studies ishwarya

Great thread from Michael Lacagnina on his fantastic new paper on B cells in neuropathic pain. So much great data in this work including some human DRG analysis done by ishwarya Stephanie Shiers Diana Tavares Ferreira Juliet Mwirigi and @aliibarry

Great thread from lead author Michael Lacagnina on our new Science Translational Medicine paper showing how B cells contribute to neuropathic pain MD Anderson Cancer Center Huge collaborative effort from Ted Price director of CAPS at UT Dallas Prof Mark Hutchinson Camilla Svensson Terry Walters Dr. Cobi Heijnen science.org/doi/10.1126/sc…

Great meeting! Thanks for organizing, Ruth!

B cells can drive #NeuropathicPain and allodynia after nerve injury by secreting IgG that accumulates and activates Fc gamma receptors within sensory neurons, shows new preclinical work from scientists at MD Anderson Cancer Center. Peter Grace, Ph.D. Michael Lacagnina scim.ag/8ov

Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders go.nature.com/40yaQTR

Thrilled to share our latest publication in Nature Biotechnology on developing a prodrug to deliver an NRF2 activator selectively at sites of oxidative stress for chronic pain relief. Great thread by Peter Grace, Ph.D. on the paper here. Congrats to all authors on this important work!

CNBP Uni of Adelaide MD Anderson Cancer Center Texas Southern University Andrew Abell Peter Grace, Ph.D. Researchers discover localised pain relief using known chemical reaction #NBTintheNews via Uni of Adelaide adelaide.edu.au/newsroom/news/…

Peroxides localized at oxidative stress sites trigger prodrug release for treating chronic pain in mice, according to a paper in Nature Biotechnology. go.nature.com/4facnUy

CNBP Uni of Adelaide MD Anderson Cancer Center Texas Southern University Andrew Abell Peter Grace, Ph.D. Targeted treatment of oxidative stress via peroxide-activated prodrug #behindthepaper communities.springernature.com/posts/targeted…

Our paper is on preprint, uncovering a molecular mechanism potentially involved in human chronic neck pain in patients susceptible to infiltration of IgG4-producing B cells. Ted Price director of CAPS at UT Dallas UW Anesthesiology & Pain Medicine UW Clear Center #ChronicPain medrxiv.org/content/10.110…

1⃣ Modified NRF2 Activator: A novel drug targets oxidative stress, reversing #ChronicPain with fewer side effects. Dr. Peter Grace, Ph.D. and his team are leading this game-changing research for patients with diseases linked to oxidative stress! #PainManagement #PharmaInnovation