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🌟IgG4RD: Lessons from the first 20 years🌟by Prof John Stone ⭐️Lesson 1- IgG4RD is a variable vessel vasculitis ✨Can cause small vessel vasculitis of the skin ✨One of few vasculitis causing coronary arteritis in adults ⭐️Lesson 2- IgG4RD is more common and severe in males

🌟Identifying treatable traits in SSc - Inflammation and Fibrosis🌟 by Dr. Dinesh Khanna Dr. Dinesh Khanna ⭐️What we need to evaluate? 1. Signs and symptoms ✨Early SSc, associated disability, internal organ involvement, tendon friction rubs- respond better to Immunosuppressive

Takeaways from SIG Sjogren:1)368 patients ,14.6:1 F:M, only 10% had subjective sicca at onset,70% had subjective & objective sicca in f/u, 2)50% had joint, 12% had FMS, only 7.7% had first contact with Rheumatologist 3)3% Lung and 6% renal 4)62% fulfilled ACR/EULAR 2016 criteria

Autoimmunity and infection by Dr.Justina Tan #IRACON2024 #rheumatology #Rheumtwitter #MedTwitter Important points 1.Various mechanism-super antigen,molecular mimicry ,cryptic antigen activation,bystander activation 2. Covid 19 and Autoimmunity - superantigen , molecular mimicry

🌟 **Foot Health in Rheumatology** 🌟 Ankylosing Spondylitis (AS) and other rheumatologic conditions heavily impact foot health. Here’s what you need to know: 1. **Anatomy Matters**: Understanding the ankle & foot structure is essential for insights into joint function. 🦶🔍 2.

#scleroderma 1. why is SSc- a 'fibrotic disease' treated with immunosuppressive? 2. Why dont every patient with early SSc respond to immunosuppressive? the lessons lie in understanding the underlying mechanisms of early SSc and molecular heterogeneity. IRACON 24

--- #IRACON24 🌞 **Sun Protection Essentials from IRACON 24 - LUPUS SYMPOSIUM** 🌞 Protect your skin against harmful UVA and UVB rays with these crucial tips: 1. **Know the Risks:** UVA & UVB can activate skin dendritic cells and potentially trigger lupus flares. 2. **Cover

✅Prophylactic anticoagulation in nephrotic syndrome 🅰️Hypoalbuminemia (<2) with one of following 🎯Proteinuria >10gm/day 🎯BMI> 35 🎯Heart 💔 failure 🎯Genetic predisposed for thrombosis 🎯/Recent abdominal surgery KDIGO Int Society of Nephrology

#MedTwitter #anatest For doctors confused on Ana testing 👇 ANA Testing in Rheumatology: Methods & Interpretation (case based) 1/ 📢 Let’s demystify ANA (anti-nuclear antibody) testing in rheumatology! A positive ANA test doesn’t always mean you have an autoimmune disease,

🚨Our latest publication ACR_Journals American College of Rheumatology Dr Nishant Kamble MD DM Sundaram T G #Clinicalpearls 🧐Joint pain with CHIK sign A quintessential diagnostic clue, yet frequently overlooked #tropicalrheumatism 🌏🦟🦠 📖Read more: doi.org/10.1002/acr2.7… #Rheumatology #MedTwitter

Had d privilege of hosting Dr. Shikha Singla from University of Wisconsin & Director of PsA program! She delivered an insightful lecture on "Difficult to treat PsA," engaging with residents & offering invaluable opinions on our cases.A truly enriching experience!

•🔥 Monogenic vasculitis: DADA2, HA20, SAVI, COPA, LAVLI, VEXAS—rare but real! Affects all vessel sizes, early onset (except VEXAS in elderly). •⚡ DADA2: Livedo racemosa, strokes, skin necrosis—hit by anti-TNF & HSCT. •🌟 HA20: Behçet-like—ulcers, uveitis, venous thrombosis

🔥 HLH decoded! 🔥 📢Dive into our latest review Clinical & Experimental Immunology British Society for Immunology exploring the tangled web of HLH/MAS pathophysiology with fresh insights from animal models. Bench to bedside💥 #MedTwitter 🧵#Immunology nerds👇 #HLH #MAS #CytokineStorm 📰 doi.org/10.1093/cei/ux…

📢Hot off the press 📰QJM: international journal of medicine Association of Physicians, GB & Ireland Oxford Academic ✨Don’t overlook👁️in lupus ✨Subtle clues➡️major significance ✨Cytoid bodies🚦microvascular injury➕disease activity Dr Nishant Kamble MD DM #Lupus #RheumTwitter #MedTwitter academic.oup.com/qjmed/article-…

🎉 Congratulations to Dr. Rajat Sahu , Kishan Majithiya, and co-authors on their insightful case-based review published in Modern Rheumatology on the rare coexistence of lupus with eosinophilic fasciitis! A valuable addition to the literature. 👏🧠📚 #Rheumatology #Lupus

Vasculitis Imaging-MRI Best Tool: Black Blood MRI → direct vessel wall view. Hallmark: Concentric wall thickening + strong enhancement. D/D's: Atherosclerosis-eccentric RCVS-no enhancement Dissection-eccentric + T1 bright Recommendation: Use HRVW MRI for suspected CNS vasculitis

1️⃣ MCTD = overlap syndrome (lupus + scleroderma + myositis) + hallmark anti-U1-RNP antibodies. 2️⃣ 2019 criteria: sensitivity 90.6%, specificity 98.4% → more accurate diagnosis than older ones. 3️⃣ Nailfold capillaroscopy reveals microvascular damage. Key link: changes predict

AIRDs commonly affect the stomach through inflammation, impaired motility, vascular damage, or immune-mediated injury. Symptoms such as gastroparesis, dyspepsia, ulcers, or bloating, driven by mechanisms like fibrosis, immune complex deposition, or reduced secretions.

Newer Ab's in SLE- *High disease activity is associated with IgG/IgA antibodies against HMGN5, IRF5, TGIF1, LIN28A. Organ associations: *Renal & CNS involvement → IgG anti-LIN28A (~50% positivity) *Arthritis/Musculoskeletal → IgA anti-FOSL2 (arthritis-specific) IRACON 2025

Either or combination of following helps me in my rheumatology practice (we deal with often complex , organ life threatening diseases and scenarios, potent drugs) Start with perspective “Let’s look at this calmly. Every medicine helps control disease and prevent damage. Leaving