Beyond matrix #stiffness: Dr. Ioannis Zervantonakis and colleagues discuss how the therapeutic response is impacted by ECM composition and stiffness, interstitial fluid pressure, and elevated mechanical forces. bit.ly/3DMQkSO

Branch-duct Intraductal Papillary Mucinous Neoplasm (#IPMN) with Low-grade Dysplasia (w/ KRAS/GNAS mutations preoperatively). Thick mucin obstructing the side branch of the main pancreatic duct causing #pancreatitis. #Pathology #pancreaticcancerawarenessmonth #PancPath #GIPath

NEW content online! Decoding the basis of histological variation in human cancer dlvr.it/T0TsJw

Ikigai is a 🇯🇵 concept representing “a sense of purpose in life”. It has been suggested as one of the reasons for the longevity of 🇯🇵 people, and observational studies found reduced risk of mortality from all causes among individuals feeling more ikigai. sciencedirect.com/science/articl…

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…

Running your own lab (watch the whole 7 minutes, it's priceless)

Good CAF or bad CAF, that's the question! In our new paper Cancer Cell we use #imagingmasscytometry to unravel the prognostic effect of cancer-associated #fibroblast (CAF) heterogeneity&their effect on therapy in 1000+ Unispital_USZ lung cancer patients cell.com/cancer-cell/fu…

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…

Patho-DBiT allows for spatially exploring a wide range of rich RNA biology (alternative splicing isoform, SNV mutation, non-coding RNAs, microRNAs, RNA dynamics, etc) with superior sensitivity from clinical archival FFPE tissue samples!!!

Happy Lunar New 2024

Happening now 9AM- 12:30PM! “Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma” #AACR2024 authored by our TeamLab members Julien Dilly, Shalek Lab, S. Chugh,S. Dougan, B. Wolpin, Jonathan A. Nowak, Peter Winter, A. Aguirre

It's out! We report 3D mapping of human pancreatic precancer and associated genetic alterations. With the brilliant Ashley Kiemen and Denis Wirtz . Tweetorial to follow soon. nature.com/articles/s4158…

NEW content online! Developmental origins shape the paediatric cancer genome dlvr.it/T6L4X9

We are delighted to celebrate Dr. Laurie Glimcher Laurie Glimcher MD , a valued member of our board, for her remarkable tenure as President and CEO, now President Emerita, of Dana-Farber. We also look forward to continued collaboration under the new leadership of Dr. Benjamin Ebert, a

Check out our updated #bioRxiv preprint on #bionformatics #Rstats method CRAWDAD (Cell-type Relationship Analysis Workflow Done Across Distances) for quantifying cell-type spatial relationships in #spatialomics data 📰: biorxiv.org/content/10.110… 💻: github.com/JEFworks-Lab/C…

New nature research paper: A pathology foundation model for cancer diagnosis and prognosis prediction. Kun-Hsing Yu Nancy Lin, MD Eliana Marostica Lynette Sholl David Meredith Shuji Ogino pubmed.ncbi.nlm.nih.gov/39232164/

💫NEW: Tamagawa, Fujii et al. show that squamous differentiation in human #PancreaticCancer can be attributed to TP63-mediated lineage conversion and epigenetic reprogramming that depends upon a hypoxic and #Wnt-defective niche. 👉🏾rdcu.be/dUBOs nature.com/articles/s4155…

Struggle with “ballooned” hepatocytes? Dr. Allende has some useful tips! Hans Popper Hepatopathology Society USCAP #USCAP2025

Sharing Andrew Bellizzi 🇺🇦 wallhangers Hans Popper Hepatopathology Society USCAP These are gold!!!

#USCAP2025 #ICTN