One of the best ways to reduce hallucinations with LLMs is by retrieving useful, factual information and injecting it into the LLM’s prompt as added context. Although this might sound complicated, it’s actually quite easy to implement with standard vector search functionality…

Have you been seeking an alternative to LSTMs for de novo drug design? Have tried GPTs but couldn't find what you hoped for?😕 Look no more! We've just the thing for you: Structured State Space Sequence Models (S4) for de novo drug design🎉 A thread🧵(1/6)

In 1938, Julian Layton was in Vienna helping to extract Jews from Austria – then the architect of the Final Solution rang. Here, our writer Jasper Rees tells the story of his great uncle. Read the full article here: telegraph.co.uk/tv/2023/10/28/…

New! We’ve just put up a note evaluating the latest, in-development version of AlphaFold (“AlphaFold-latest”). This is a preview - development is still in progress - but performance across a wide range of tasks is striking. deepmind.google/discover/blog/… Highlights in the thread. 1/7

I got into ml because the other option was organic chemistry

Ever since the invention of the car cities have been changing, and in the 1930s people like Norman Bel Geddes predicted exactly what would come to pass: cities designed for cars rather than people. A feeling captured rather well by this cartoon...

some NeurIPS highlights: LDM tutorial was great. the 1st part is a must-watch, the 2nd part is full of references for recent advancements, and you need to check the 3rd part if you're planning to use LDMs for something other than images/videos. neurips2023-ldm-tutorial.github.io

Use inverse folding likelihoods as an unsupervised protein sequence optimizer. Varun Shanker Theodora Brian Hie Peter Kim

The first Practical Cheminformatics post of the year is a retrospective of papers published in 2023, “AI in Drug Discovery 2023 - A Highly Opinionated Literature Review”. practicalcheminformatics.blogspot.com/2024/01/ai-in-…

here is sora, our video generation model: openai.com/sora today we are starting red-teaming and offering access to a limited number of creators. Tim Brooks Bill Peebles Aditya Ramesh are really incredible; amazing work by them and the team. remarkable moment.

Raising children on the eve of AI Julia Wise 🔸 juliawise.net/raising-childr…

Our fragment-based molecular generator, FragGT has been published with code. Had a lot of fun with this while on my year out. Thanks to Nathan Brown and BenevolentAI for supporting open source science #guacamol chemrxiv.org/engage/chemrxi…

We’re really happy to share our preprint demonstrating the atomically-accurate design of single-domain antibodies (VHHs) with RFdiffusion!

OpenFold paper is now out in Nature Methods. Timely. I’ll say more about AF3 at the end of this thread, but first I wanted to highlight what’s new since our initial release. (1/9)

Nice review of Generative artificial intelligence for de novo protein design sciencedirect.com/science/articl…

Not an ML expert, but want to understand AlphaFold3 (AF3)? I wrote a simple-to-understand AF3 field guide and sprinkled my opinions in along the way. The full essay is linked at the END of the thread. Here's a TL;DR 🧵

New blog post alert! 🚨 I write about AlphaFold3, how it works, where it works well ✅ (and where we think it might not ❌) and what it means to the TechBio landscape more broadly (if you decide to believe me). 🧬 (1/7) 🧵 open.substack.com/pub/harrisbio/…

How do healthy tissues evolve to become cancerous? Delighted to share our latest research tracking the somatic evolution that occurs in the decades before AML. 👇Implications for early detection and early interception. biorxiv.org/cgi/content/sh…

Big congrats to Aaron Lou, Chenlin Meng & Stefano Ermon on winning an #ICML2024 Best Paper Award for: Discrete Diffusion Modeling by Estimating the Ratios of the Data Distribution Exciting work improving diffusion models for symbolic data like text. arxiv.org/abs/2310.16834

Off to #NeurIPS2024 next week where we are presenting our approach to diffusion sampling for generalised protein inpainting problems such as floating motif scaffolding and sequence editing. Drop by the AIDrugX Workshop or drop me a message if you're interested! synteny.ai