Dr Jon Krell (@drjonkrell) 's Twitter Profile
Dr Jon Krell

@drjonkrell

ID: 841250876824158208

calendar_today13-03-2017 11:33:33

26 Tweet

88 Followers

11 Following

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With the newer drugs on the horizon this may change. A recent study shows for patients surviving for many years, this effect may be lost x.com/OvarianCancerU…

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Available via the CDF in patients just diagnosed with OvCa who are having their first chemotherapy but depends on the stage of the OvCA. x.com/OvarianCancerU…

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Sometimes BRCA+ cancer cells become resistant to PARP inhibitors. We don't yet know if giving a different PARP inh in this situation helps x.com/OvarianCancerU…

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there will however be many drugs or drug trials that I am sure your oncologist can suggest for you. x.com/OvarianCancerU…

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Probably because when BRCA is abnormal in cancer cells, chemotherapy & PARP inhibitors are more effective. Other reasons not yet known x.com/OvarianCancerU…

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Not abnormal. OCA & our team are working to spread the message to GPs and the public about BRCA to help prevent cancer and diagnose earlier x.com/Gilana25/statu…

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carboplatin is often very effective in ovarian cancer and in BRCA+. Keep going with carboplatin if effective. T-cell still experimental x.com/OvarianCancerU…

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But PARP inhibitors are used as maintenance treatment after carboplatin in BRCA+ OvCa in certain circumstances. Discuss with your oncologist x.com/OvarianCancerU…

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If further relapse after 6 months from last platinum & carboplatin still effective then olaparib would be available as maintenance on NHS x.com/OvarianCancerU…

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If BRCA+ & eligible for olaparib then this would be best option. Immunotherapy still experimental and available in certain clinical trials x.com/OvarianCancerU…

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recent results from trials show that some patients with BRCA+ OvCa can benefit for many years from PARP inhibitors. Unfortunately not all x.com/OvarianCancerU…

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not clear but not yet- still no good early screening test for OvCa. OCA funded research at Imperial e.g. PROGRESS, is looking at this x.com/OvarianCancerU…

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Primary prevention measures such are prophylactic surgery to remove ovaries and fallopian tubes at the appropriate age will help reduce risk x.com/OvarianCancerU…

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We hope in the future to have screening test to detect ovarian cancer early & to use them in BRCA+ people and other at high risk of OvCa x.com/OvarianCancerU…

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PROGRESS is a pilot study aiming to assess to role of 'population testing' for genetic risk of OvCa and other cancers. x.com/OvarianCancerU…

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We developed an algorithm to help determine persons risk of OvCa & Breast Ca by analysing genetic differences in saliva & knowing family Hx. x.com/OvarianCancerU…

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This algorithm is experimental but we hope to validate it in the study and also assess the view of the public of population risk screening x.com/OvarianCancerU…

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Not certain. only 2% of OvCa are due to lynch syndrome. Survival in known lynch may be better because it is often diagnosed earlier stage x.com/OvarianCancerU…

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Currently only people living in the West London Area attending their GP practice. If successful we want a national study x.com/OvarianCancerU…