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Excited to share the work of Kaitlin Hart, a graduate student in our lab, who worked to solve the novel binary structure of Anti-Müllerian hormone (AMH) bound to type II Ser/Thr kinase receptor, AMHR2. pnas.org/content/118/26….

Check out our new 3D protein display featuring structures solved by Seegar Lab, Rhett Kovall Lab, and us Tom Thompson Lab!! Thank you to the U of Cincinnati Engineering and Applied Science digital fabrication lab for making this collaboration possible.

New Research: Molecular Mechanisms of AMH Signaling: Anti-Müllerian Hormone (AMH) is a secreted glycoprotein hormone with critical roles in reproductive development and regulation. Its chemical and mechanistic similarities to members… frontiersin.org/articles/10.33… #Endocrinology #Endo

Check out the latest mini review from our lab discussing the exciting biochemical advances in understanding the signaling mechanism of AMH and its receptor, AMHR2. Special congratulations to Drew Howard, one of our 2nd year graduate students! frontiersin.org/articles/10.33…

In his 1952 classic, Turing showed that ≥2 interacting, continuously diffusing morphogens can spontaneously generate beautiful biological patterns. On a discrete cell lattice, we find that 1 morphogen is enough for stable spatially periodic patterns cell.com/cell-systems/r…

Join me in supporting Emma Curtis via ActBlue secure.actblue.com/donate/emmafor…

Two decades ago Avigdor Eldar & Barkai Lab introduced concept of shuttling, in which protein circuits push morphogens away from their source, or smush them into narrower regions. We have now reconstituted shuttling in mammalian cell culture: science.org/doi/10.1126/sc….

A great course, and lots of fun (at least for me)!

Very cool! I believe this counts as manual blotting, yes?

Structural Basis of Non-Latent Signaling by the Anti-Mullerian Hormone Procomplex biorxiv.org/cgi/content/sh… #biorxiv_molbio

We are thrilled to share our latest preprint on the Anti-Müllerian Hormone and its unique signaling pathway. Our first ever cryo-EM structure represents a breakthrough over 40 years in the making. 🧬🔍 (Drew Howard) Check out our findings here: biorxiv.org/content/10.110… 1/10

Hey all new(ish) structural biology PIs out there - I started a slack workspace geared toward us! If you’d like to join, DM me your email and method(s) of choice, and I’ll add you to the group.

Our lab presented six poster presentations and gave three oral presentations showcasing our latest work. 😎💪 Above all, we were delighted that Drew Howard won first award for best short talk and Jacob Mast won second prize for best poster presentation. 🏆👏🔝

Last chance to apply to the Cold Spring Harbor #cryoem course this March (application deadline is Jan 15th)! Learn all about sample prep, microscope operation, and image processing at this fun 2-week course kollman lab Jennifer Cash CSHL Courses meetings.cshl.edu/courses.aspx?c…

Baby’s First Paper! A divergent two-domain structure of the anti-Müllerian hormone prodomain | PNAS pnas.org/doi/10.1073/pn…