Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 Stomach acid evolved over millions of years. We use ATP to make the acid. While there are issues with overproduction, it makes no sense to me to expose 25-40% of the population to these potent drugs, often long term.

Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.

Static vs. cidal: it’s not complex; it’s simply incorrect Brad Spellberg Todd C. Lee Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 doi.org/10.1128/aac.00…

"However,the concept of static/cidal antibiotics is neither complex nor context-dependent;it is rather a myth. Regrettably,this dogma continues to be raised in modern literature despite two fundamental flaws" Honored to contribute to this important letter led by 🌟 Brad Spellberg

It's out on #AAC (ASM): a concise but incisive letter on the lingering false myth of "bacteriostatic" #antibiotics as inferior to "cidal" ones. What an honour to be among authors in a group led by Brad Spellberg. #IDXposts rita murri journals.asm.org/doi/10.1128/aa…

The Static/Cidal letter to the editor at AAC made Google News! First time I’ve ever seen that happen to a letter to the editor—must be a ton of people reading it!

I think I just brainwashed myself into liking the midline decimal.

I accidentally just added Michael Garron as a co-author on a paper. For context, he’s a hospital in Toronto.

Emily McDonald Amir Hadid

⌚ Une IA utilisant des capteurs portables détecte l’inflammation avant les symptômes — avec 90 % de sensibilité. Centre universitaire de santé McGill McGill Medicine and Health Sciences Par Jensen, McDonald et Hadid. 👉 rimuhc.ca/fr/-/des-cherc…

This research was led by Amir Hadid & wouldn’t have been possible without his extraordinary effort & the collaboration of Emily McDonald, Phil Dixon, Qianggang Ding, Christopher Phillip, Audrey Trottier, Oussama Jlassi, Matthew Cheng, Jesse Pappenburg, Michael Libman & others

New tool helps cut unnecessary meds in seniors. MedSafer, co-developed by Drs. Emily McDonald & Todd Lee, helped deprescribe in 36% of residents—3x more than usual care. MedSafer 🔬 rimuhc.ca/en/-/new-tool-…

Un plaisir de discuter avec Pierre-Alexandre Bolduc de l'étude clinique randomisée sur la déprescription en CHSLD grâce à MedSafer MedSécure est un logiciel qui aide les médecins à déprescrire. Il a été inventé par Emily McDonald et Todd C. Lee. CADeN ici.radio-canada.ca/ohdio/premiere…

Okay, due to popular demand, I am pleased to introduce a new Master Table for oral vs. IV abx. ID:IOTS podcasting / idiots-pod.bsky.social Alí Sebastian Meza Josh Osowicki Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 This & new reference for frieking bubonic plague--yes folks, frieking bubonic plague!--added to the website. bradspellberg.com/oral-antibioti…

International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding. 🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idxposts jamanetwork.com/journals/jamai…

Studies were of low to moderate quality and their results indicated a high probability that shorter antibiotic prophylaxis durations (including ZERO days) were noninferior to longer durations for all-cause mortality, but not for early rebleed or bacterial infections.

Another collaboration led by PhD student (and core internal medicine resident) Connor Prosty I think guidelines should be less explicit on duration (I think 3 days maximum) and I welcome a large modern RCT in this space. Emily McDonald Brad Spellberg

Finally published 🆕🔥DOTS RCT Among participants with complicated S aureus bacteremia who achieved blood culture clearance, dalbavancin was not superior to standard therapy for achieving a more desirable outcome at day 70 Todd C. Lee Brad Spellberg jamanetwork.com/journals/jama/…

Shorter durations of #antibiotic prophylaxis, including no prophylaxis, appear noninferior to longer durations for preventing mortality in patients with #cirrhosis and upper gastrointestinal bleeding. ja.ma/4lYhU3W @bradspellberg Todd C. Lee

One cannot look at the actual meta-analysis plots (below) & be at all worried that holding abx increased mortality. If anything, it looks like shorter or no abx improved survival over giving the abx. The trend becomes even stronger for not giving abx for RCTs after 2004.