What are the rules of the immune receptor code? In my talk Kavli Institute for Theoretical Physics last Friday I summarised our recent findings, provide a perspective on why ML approaches have so far not achieved breakthrough success, and propose a path forward: online.kitp.ucsb.edu/online/viralim…

New de-novo TCR design preprint from dhuv.io just dropped: TCR-TRANSLATE: Conditional Generation of Real Antigen Specific T-cell Receptor Sequences biorxiv.org/content/10.110…

Exciting to see PLOS moving away from Article Processing Charges. Hope they crack a better business model that other publishers can follow. buff.ly/3A2U5p3 #OpenScience

🚨Seems JCVI only takes into account hospitalisation & death from acute #Covid, no mention of #LongCovid, which considering the vast impact it is having including on the economy, is astonishing. Omission of Long Covid & all other clinically vulnerable is utterly negligent.

This is a very exciting opportunity to join a project across Ewan Birney and Open Targets teams at EMBL-EBI - apply now!

Our work on antibody mass spec benchmarking is out! We created one of the largest antibody bottom-up proteomics datasets to query the impact of many experimental and computational parameters on the recovery of biological ground truth. See thread below for details by Khang Le Quy.

Incredibly short-sighted. And I'm being very polite here. Puts an enormous number of vulnerable people at risk. Would love to understand the modelling behind this and to what extent (I'm guessing none) they accounted for the health/economic/workforce impact of LongCOVID

Brilliant QImmuno meeting yesterday. Thank you to all the organisers - Luis Zapata, Beatriz Monterde Martinez and Tahel Ronel for all of the hard work. Inspirational as ever, excited for the next one. Thank you to Andreas Tiffeau-Mayer and others for starting this excellent series.

Next gen alphafold, future generative models, holy-grail models for drug design, and agents for actual science. I’m looking for builders to join our incredibly talented ML scientists and engineers at Isomorphic Labs to create the future of drug design job-boards.greenhouse.io/isomorphiclabs…

The UK government has ambitious plans for a National Data Library, and a lot of the important technical choices remain to be made. Together with Wellcome, @esrc is running a Technical White Paper challenge to invite proposals for how to make it work best!

This Tuesday, 11/19 @ 4 pm EST, we'll have Will Hua present "EnzymeFlow: Generating Reaction-specific Enzyme Catalytic Pockets through Flow Matching and Co-Evolutionary Dynamics" Paper: arxiv.org/abs/2410.00327 Sign up on our website to receive Zoom links via email!

I am happy to say this work is now published in Frontiers in Immunology! frontiersin.org/journals/immun… Again, I would like to thank my supervisors hashem and Oxford Protein Informatics Group (OPIG) for their guidance and Dr Chris Thorpe and Prof. Jamie Rossjohn for their collaboration on this work.

Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates pnas.org/doi/epub/10.10… PNASNews

🧵 1/5 New Nature Microbiology study reveals H5N1 bird flu evolution: Scientists measured infectious virus particles in air from infected ferrets, finding recent strains show low but increased ability to be expelled into air compared to older variants.

This year's chemistry laureate David Baker has arrived in Stockholm today prepared for our cold weather ❄️

Work involving Dan Nissley (from his Postdoc with Oxford Protein Informatics Group (OPIG)) shows the importance of running simulations of an antibody's "reach" to understand its viral neutralisation potential. Read the paper published in Nature Communications (Nature Communications) here: nature.com/articles/s4146…

Two very exciting roles in this brilliant group. The deadline for one is next week, the other the end of January, so get applying and do some work that really matters with excellent people!

Many top academic AI researchers are GPU poor. The Sovereign AI Unit wants to change this story. We are seeking ambitious AI research proposals for UK academics aiming to take their research to the next level. Read below to find out more and apply 🧵👇

CASP is getting cut by NIH... 😢 (Anyone with extra funds wanna help support perhaps the most important competition of the century?) science.org/content/articl…

Calling T-cell immunologists and machine learning experts. Just over a week to go to submit an abstract for oral or poster presentation, or to register for the hackathon. It will be lovely to see you in Oxford in late September! cvent.me/94L9A5