Beck: Aging & MS. Peak age for smoldering MS lesions? Age 60. New lesions are more likely to become chronic active (paramagnetic rim) lesions with increasing age. New lesions are less likely to remyelinate with increasing age. #ACTRIMS

Osborne: Microbiome differences seen in people with depression, anxiety, Parkinson’s, Alzheimer’s and multiple sclerosis #MS compared to people without these conditions. #ECTRIMS

Dwyer: Ocrelizumab #Ocrevus reduced the number of cortical lesions by 75% and volume by 86% compared to placebo in Oratorio in primary progressive MS #PPMS patients. Uses AI-DIR and FLAIR squared techniques. #ACTRIMS

Lincoln: Autoimmune disease such as MS, Celiac disease. rheumatoid arthritis and Crohn’s share genetic risk in a complex manner. Particular risk foci (and mechanisms) are shared in autoimmune diseases and affect specific immune cells. #ACTRIMS

Rotstein: in Ontario 🇨🇦, infectious mononucleosis predates MS by a median of 11.5 years. On the group level, duration of the MS prodrome is similar in those with and without a mono history. #ACTRIMS

Interesting #ACTRIMS session on CAR-T. Goal in #MS would be to deplete B cells inside CNS, like B cell follicles. Pretreatment requires pheresis over several hours, chemo with fludarabine + cyclophosphamide and 7-14 day post-treatment observation. Early MS trials underway.

Gilmartin: Optically pumped magnetoencephalography (OPM-MEG) is a non-invasive, wearable technology that images brain activity in real time. Delayed response on tasks like moving a finger to a prompt in people with #MS. #ACTRIMS

Wells: Ear stimulation stimulates #remyelination in mice via the vagus nerve. Could it work in people with #MS? #ACTRIMS

Shinohara: #AI can be used to help distinguish #MS from other causes of white matter lesions such as migraine or blockage of blood small blood vessels. #ACTRIMS

Brugarolas: PET scan tracer [18F]3FAP based on the 4-AP #MS medication targets K+ channels on demyelinating axons. May be a tool for future #remyelination research. 🔬 #ACTRIMS

Oh: Paramagnetic rim lesions #PRLs correlate with risk of disability accumulation in people with #MS. The benefit of #tolebrutinib vs. teriflunomide on 6-month confirmed disability worsening CDW was more evident in participants with PRLs at baseline. #ACTRIMS

Conditions like #AE, #MOGAD and #NMOSD can cause spasticity and weakness, affecting mobility and daily tasks. Early diagnosis & treatment are crucial for symptom management & enhancing quality of life. Learn about both directly from Barry Singer MD 🧠: youtu.be/a3QCaerCuPo?si…

🌞Please join me in person or free livestream May 14 to support the MS Assoc. of America. Thrilled to be selected as the 2025 Mission Honoree. Tyler Campbell is hosting! Must Stop MS! theMSguide.com 🧠 Dr. Brandon Beaber Aaron Boster MD Girl with MS Dr. Gabriel Pardo Dan & Jen Digmann Sal Napoli MD

🎇Hi, all! MS Assoc. of America Improving Lives Benefit is LIVESTREAMING free this Wednesday May 14 at 7:45 PM EDT/6:45 PM CDT 45 min. program. Super grateful to be selected as the 2025 Mission Honoree. Love for you to join us!! Register at: bit.ly/4j5zKjp

Excited to welcome Dr. Jamie Holloman brainboyneurology as new co-host of the #MSLivingWell podcast! 🎙️ 1st episode! Secondary Progressive MS: Next Chapter 🍎 apple.co/4jddhRk 🎧 bit.ly/4j8wh3D Moein Amin Alise Carlson Daniel Ontaneda Mary Rensel MD FAAN ABIHM #neurotwitter

Secondary Progressive #MS: Next Chapter🎙️ NEW MS Living Well podcast with new co-host Jaime Holloman & Guest Dr. LaGanke! 🍎apple.co/4jddhRk 🎧bit.ly/4j8wh3D Dan & Jen Digmann Must Stop MS! Mark Webb Dr. Brandon Beaber theMSguide.com 🧠 Laura Kolaczkowski 😷😷😷😷 Tyler Campbell

Secondary Progressive #MS: Next Chapter🎙️ NEW MS Living Well podcast; New co-host Dr. Jaime Holloman & Guest Dr. LaGanke! 🍎apple.co/4jddhRk 🎧bit.ly/4j8wh3D Jacqueline Nicholas MD MPH Celia Oreja-Guevara Klaus Schmierer🎗️🇺🇦 Dr. Gabriel Pardo Jaime Imitola MD., FAAN Professor_Bart Sponsor: TG Therapeutics

🚀Boosting Brain Health: Blueprint for MS New MS Living Well Podcast 🎧🚶‍♀️🥗😴🧘‍♀️ bit.ly/3FyR2b0🍏apple.co/4jHbiow Klaus Schmierer🎗️🇺🇦 Dr. Gabriel Pardo AnnekeVdWalt Celia Oreja-Guevara Ahmed Z Obeidat, MD, PhD Professor_Bart Sponsor: TG Therapeutics

🚀 Boosting Brain Health: Blueprint for MS New MS Living Well Podcast: Lifestyle medicine doc living with MS Lisa Doggett & Dr. Miravalle! bit.ly/3FyR2b0🍏apple.co/4jHbiow Jacqueline Nicholas MD MPH Sal Napoli MD Trishna Bharadia BA(hons), MFPM(hon) Joe Sabatino #NeuroTwitter Bev