NEW content online! Identification, functional insights and therapeutic targeting of EMT tumour states bit.ly/3IJ8haZ

Intraductal Papillary Mucinous Neoplasm and Pancreatic Cancer: Opportunity Knocks Twice Hamada, et al. 📕 doi.org/10.14309/ajg.0… Yousuke Nakai 中井　陽介 Millie Long Jasmohan Bajaj

JAMA loves to hate on odds and odds ratios. Apparently only bookees, gamblers, poker players can understand odds; odds just cannot be understood by clinicians, and clinicians who use odds cannot be trusted to inform patients

#DCRJournal visual abstract | Evaluating the Impact of Induction and Consolidation Total Neoadjuvant Therapies Compared to Conventional Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Network Meta-analysis: bit.ly/43PErJz

📢 Phase III RCT in locally advanced #OPSCC: proton 💠 vs conventional #radiotherapy 🔆 ❌ No diff. in 12-mo gastrostomy rate, QOL, or swallowing. ⚖️ Similar 2-yr local control & OS (~95%). 👉 High-quality IMRT remains standard; IMPT not required. #ASTRO25 #RadOnc ASTRO

Is there an alternative to HA-WBRT+memantine to decrease risk of new brain mets? Yes, in this randomized trial Tumor Treating Fields prolongs time to intracranial progression w/o affecting QoL or cognitive function sciencedirect.com/science/articl…

WOW! 🧠METIS trial (n=298) in #lungcancer brain mets: SRS ➕ TTFields ⚡vs SRS alone ✅ TTFields delays intracranial progression (HR 0.72, p=0.044) 📉12-mo progression: 47% vs 59%; ⬆️ with immunotherapy (HR 0.63) ❌No QoL / cognition decline; AEs mild skin #ASTRO25 #RadOnc

“Precision Medicine” is largely based on false premises and misunderstanding of natural variation; both between treatments, patients, patient x treatment, and within patient ht Stephen John Senn

Dr Hiroshi Onishi 🇯🇵 - guru of #lungcancer,l turns his attention to #kcsm 💥 Multicenter phase II (Japan, n=49): SBRT (50–70 Gy/10fx) for localized #kidneycancer ✅ Local control 100% at 5 & 10 yrs 📈 10-yr CSS 87% (97% if SBRT was initial therapy) 🩺 Few grade 3–4 GI AEs;

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🧬 dMMR/MSI-H resectable GEA (IPD pooled, n=197) 🧪 Neoadjuvant ICIs vs FLOT: pCR 61.9% vs 3.7% | MPR 78.6% vs 10% | ↓ypN+ 14.3% vs 37% | ↓ypT4 📈 EFS/OS ≈ surgery±chemo 🎯 ICIs preop = higher pathologic response, rationale for organ-sparing 🔗 doi.org/10.1200/JCO-25…