🔬 **Unpacking Cutaneous Lupus Erythematosus (CLE)** 🦠 1. **Genetic Links**: - Genetic risk factors connect to immune dysfunction similar to #SLE. - **Key players**: ITGAM (DLE) & FCGR2A ( Malar rash ) are associated with lesion types. 🧬 2. **Sex Bias**: - CLE shows

Exploring the Role of Z-DNA in Autoimmune Photosensitivity ‼️ - **Investigated Diseases:** - Systemic Lupus Erythematosus (SLE) - Cutaneous Lupus Erythematosus (CLE) - Dermatomyositis **🌞 Key Findings:** - **UV Light** damages mitochondria, leading to Z-DNA

•🔥 Neutrophils key in cutaneous lupus erythematosus (CLE), seen in 70%-80% of SLE cases, driving skin lesions. •🎯 NETs formation (DNA/histones/proteins) detected in lupus panniculitis, subacute/acute CLE, boosting autoantibody production. •📈 LDGs in SLE blood surge NETs,

Did you know VEXAS syndrome is shaking up how we see Relapsing Polychondritis? Here’s the showdown between VEXAS-RP and classic Idiopathic RP: 🚨 •Nasal chondritis? Way less common in VEXAS-RP – it’s not your typical flare-up! 👃 •Inflammation levels? Sky-high CRP (median 64

🚨 Breaking: New Consensus on Monitoring JIA-Associated Uveitis in Remission! 👀 Kids with JIAU finally get tailored eye checks to catch flares early & save sight. From global experts! Here’s the scoop: 🔹 Remission Defined: No inflammation for 6+ months on meds or 3+ off – zero

🚨 Lung Breakthrough: Inhaled GM-CSF Revolutionizes Autoimmune PAP Treatment! From mouse experiments to miracle med—here’s the scoop on this rare, debilitating disease: 🔹 What is PAP? Rare lung disorder where surfactant builds up like “crazy paving” on CT scans, causing

🔥 Epic showdown at the S D Deodhar Rheumatology Quiz for IRACON 2025 at KGMU, Lucknow! 🧠💥 14 top teams from UP battled it out! 🏆 🥇 Champs: Dr. Ashwin & Dr. Boddi Vamsi ( IMS BHU ) 🥈 Runners-up: Dr. Raghav Narang & Dr. Surya Shukla ( GSVM , Kanpur ) 🥉 Dr. Nikhil & Dr.

MMF+MTX Outshines CYC/AZA in Takayasu Arteritis RCT! 🚀 •111 adults with active TAK randomized 2:1 to MMF+MTX vs. CYC/AZA + glucocorticoids. •Primary win: Overall response at 52 weeks higher with MMF+MTX (55.4%) vs. CYC/AZA (32.4%) – P=0.022! •Better CR/PR rates at 28 & 52

🧵 Adrenal Insufficiency in Adults – Key Updates (JAMA 2025) 1⃣ AI = cortisol deficiency → Primary, Secondary, or Steroid-induced (most common) 2⃣ Symptoms: Fatigue (95%), Nausea/Vomiting (62%), Weight loss (73%) 3⃣ Causes:  • Primary – autoimmune adrenalitis, infections  •

🔥 Scleromyositis – a distinct autoimmune entity! •🧩 Not just an overlap – sits between systemic sclerosis (SSc) & autoimmune myositis (AIM). •💪 Muscle weakness: proximal > distal, sometimes axial (→ head drop, camptocormia). •🫁🫀 Extra-muscular hits: ILD (up to 68%),

1️⃣ MCTD = overlap syndrome (lupus + scleroderma + myositis) + hallmark anti-U1-RNP antibodies. 2️⃣ 2019 criteria: sensitivity 90.6%, specificity 98.4% → more accurate diagnosis than older ones. 3️⃣ Nailfold capillaroscopy reveals microvascular damage. Key link: changes predict

🔹 Hydroxychloroquine (HCQ) boosts pregnancy outcomes in APS! •~20% of APS pregnancies face complications despite aspirin + heparin. •Meta-analysis of 750 patients shows: ✅ Live birth rate: 89.9% with HCQ vs 73.9% without. ✅ Obstetric complications: 19.3% with HCQ vs 55%

🧩 Unmasking Scleromyositis! •Rare overlap: Systemic Sclerosis (SSc) + Myositis •Often starts without skin changes → SSc sine scleroderma (45%) •Myositis = 1st non-Raynaud sign in 55% cases •🚨 Red flags: Raynaud, ANA+, nailfold capillaroscopy, GI dysmotility •91% had

🧠💔 Hypothyroidism – JAMA 2025 Review •Prevalence: 0.3–12% (↑ women, elderly) •Hashimoto thyroiditis → cause in up to 85% •Symptoms: fatigue, wt gain, brain fog, cold intolerance, menstrual issues •Untreated → ↑ CV events, infertility, miscarriage, insulin resistance

🧩 VEXAS Syndrome — Insights from The Lancet Rheumatology •Newly identified disorder at the crossroads of rheumatology & haematology •Triggered by somatic UBA1 mutation → defective ubiquitylation & immune overactivation •Leads to systemic inflammation with rheumatic-like

🚨 Hyper IgE Syndromes (HIES): Rare but serious!👇 🧬 Genetics: • Mutations in STAT3, IL6R, PGM3, ZNF341, ERBIN, CARD11, SPINK5, TGFBR1/2 • Leads to immune dysregulation + Th17 defects • Result → recurrent infections, eczema, high IgE 🩺 Clinical features: • Skin

🚨 Salivary Gland Ultrasound in Sjögren’s (pSS & jSS): Key Insights + Differentials 🔍 Why SGUS? • Non-invasive, low-cost, real-time tool for parotid & submandibular glands. • Detects early structural changes, monitors therapy. 📌 Typical SS Findings • Loss of homogeneity •

🧬 Genetic Sequencing in Rheumatology: Present 🔥 & Future 🚀 ✅ Present role •Crucial for monogenic diseases → IEIs (~500 types) •Reveals hidden mimics: •SOCS1 LOF → SLE-like •IKZF1 GOF → vasculitis, vitiligo, Evans, IgG4-RD •UBA1 mutations → VEXAS •Clinical