Fantastic perspective in Nature Methods by Ali Max Erturk: Deep 3D histology powered by tissue clearing, omics and AI

Thanks FranziG for putting these ChIP protocols and analyses together. Happy to contribute with ours on adipocytes and brown adipose tissue. KenDyar Uhlenhaut Lab CRC/TRR-BATenergy Helmholtz Diabetes Center (HDC)

I'm excited to introduce MouseMapper, an AI tool I've been working on in the past months, that enables us to study whole body changes in mice! Check out Ali Max Erturk's tweetorial about what we did, and why it matters!

Excited to be a part of the team behind MouseMapper! 😎 Our new AI tool uncovers how diseases like obesity impact the body at a cellular level, from facial nerves to widespread inflammation 🧫🔬 Check our preprint 👇🏻

Very excited to share our newes preprint! A holistic view of the impact of a disease on the whole body on the cellular level!

Very excited to share our newest preprint! Our new AI tool MouseMapper provides a pipeline to quantify the changes in peripheral nerves and immune cells in HFD mice.

Every cell matters! Check out our new study on obesity where we used deep learning-based quantitative analysis on whole bodies of obese mice as well as we applied spatial proteomics to extract underlying molecular mechanisms of structurally perturbed nerves!

I never did like that word FORMER

MouseMapper #SciArt vDISCO whole🐭optical clearings😍 + #DeepLearning Nerve-/Tissue-Module 3D U-Net▶️ VR-based annotations of Major organs Nerve Muscle Fat CD68+ clusters (How about Vessels?😄) Obesity-associated infra-orbital nerve remodeling at whole-body level

REVIEW | Le Thuc & García-Cáceres (Helmholtz Munich | @HelmholtzMunich): Authors discuss the effect of obesity-induced systemic #inflammation on the brain, including hypothalamic circuits for whole-body energy #homeostasis & cognitive function. nature.com/articles/s4225…

New content online: The complexity of adipocyte heterogeneity dlvr.it/TCRvvm

A living transparent mouse has been a dream of many. Exciting steps have now been achieved, as reported in Science. See my and other experts' comments on this new study here: Science: science.org/content/articl… STAT: statnews.com/2024/09/05/tis… ZEIT: zeit.de/wissen/2024-09… Study:

Pfizer’s phase 2 is published! Among patients with cancer cachexia and elevated GDF-15 levels, the inhibition of GDF-15 with ponsegromab resulted in increased weight gain and overall activity level and reduced cachexia symptoms: nejm.org/doi/full/10.10…

I am looking for a partner in crime who actually understands biology in Vienna — join Aithyra to make some magic oeaw.ac.at/aithyra/news/s…

Thrilled to announce that I will be starting as an Assistant Professor at Cornell University in February! #MICCAI #miccai2024 linkedin.com/posts/johannes…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

As of today, my latest first-author publication is preprinted: We investigated if short and long white matter fibers in the human brain are different in fiber diameter, myelination, and g-ratio, using electron microscopy and deep learning approaches! biorxiv.org/content/10.110… 🧵