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Legionella possesses OTU-deubiquitinases (Lot DUBs) which hinder the host ubiquitin system. We performed structural and biochemical analysis on the Lot-DUBs and explain how Lot DUBs are different from other OTU DUBs. Donghyuk Shin Yonsei University bit.ly/4458FXc

DUB meeting in Edinburgh. It was a very insightful meeting with all the nice people. Thanks to organizers (Yogesh Kulathu, Sylvie Urbe, Michael Clague). Worthy to take 14 hrs flight, Love this supportive and creative society.

Always nice to have transit in Frankfurt! Went to the restaurant where I had my postdoc interview. Nice memory with Ivan Đikić Mohit , Alexandra, and A-jeong.

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with Teresa Thurston and Magdalena Szczesna, with rach☔️ driving our side of the project using some amazing tools built by the Geurink lab.

Excited to share our new review on bacterial effectors that follow or break the "rules" of #ubiquitin signaling. Always a pleasure to work with Cam Roberts and Tyler Franklin! embopress.org/doi/abs/10.152…

Can’t live without thinking of this sticky molecule even during holidays with my family😉😂

Love this idea! AST vs MET, Nice story from Hyun Woo (Henry) PARK Lab Yonsei University A new paradigm in cancer biology. Looking forward to see the following stories☺️

Well deserved! Congratulations!!👏

Please join us this summer as the power of Ubiquitin Signaling converges with the power of Niagara Falls for FASEB #UBPSRC. We value DEIA, are raising $ for travel awards, have fantastic speakers and are excited to select new speakers from abstracts. Joazeiro Lab

Out now in NatComms: A Chlamydia-like bacterium with a deubiquitinase repertoire similar to Legionella, but using new DUB classes for the same linkage specificities (e.g. M1, K6). #ubiquitin Universität zu Köln Cologne Crystallisation facility doi.org/10.1038/s41467…

Great pleasure to host Minji Kang from STEPI/Science & Technology Institute (Republic of Korea) to exchange about R&D #cluster structures to boost innovation & technology transfer. #clusters4future #Zukunftscluster Bildungsmisererepublik Deutschland - BRDigung HMWK Hessen Goethe-Universität HTAI Donghyuk Shin

For targeted protein degradation, which is of therapeutic interest, either PROTACs or molecular glues are used. nature presents a third modality -- intramolecular glues that bridge protein domains within the same target to facilitate their degradation. shorturl.at/mpqt3

Excited to present our latest research nature where we unveil the mystery of UFMylation, a crucial process for protein homeostasis at the ER nature.com/articles/s4158…

Great honor to be invited to the Kavli Frontiers of Science Symposium. It was a fantastic experience to prepare slides and give a talk to scholars from various fields.

For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)

2 weeks to go! Can't wait to glue with all my Ub friends at my favorite conference. Huge thanks to organizers for the fantastic lineup of speakers and sessions! Yifat Merbl lab Yogesh Kulathu Joazeiro Lab Polo Lab

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you: We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability. biorxiv.org/content/10.110… Thread👇 – with movie!!

🥳It's out! Our study reveals how Legionella pneumophila manipulates the KEAP1-NFE2L2 pathway during infection. Congratulations and many thanks to all contributors. #Autophagy #Ubiquitination #Legionella #OxidativeStress SFB 1177 Taylor & Francis Research Insights IBC2 tandfonline.com/doi/full/10.10…

Super-proud of this work by Charlotte Crowe and the entire team! It has been my dream since starting working on PROTACs >15 years ago to one day see them working in action, glued to their Cullin RING ligase and target protein. It is dream come true now! Beautiful and Thank you 🙏