Our reporter system has now been published in JVI JVirology Editors ASM with an all-new green-magenta theme . Thank you to everyone involved Molecular Virology Heidelberg @mirkocortese Christopher Neufeldt @beraticerikan @vibhu_prasad Constantin Pape! jvi.asm.org/content/early/…

Disastrous development for research in Germany that will only exacerbate the already existing problems. #IchBinHanna

Safety, tolerability and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a Phase 1, double-blind, randomized, dose-escalation study in healthy volunteers ✅ Just Accepted 🔓 Open Access 🔗 bit.ly/3Bfv86T

New data shows that our #dengue antiviral is the first to demonstrate antiviral activity in humans. This has the potential to reimagine the global fight against dengue fever. Learn more at #TropMed23 this week and explore the data at jnj.com/janssen-announ….

My MSc thesis project is finally published in JVirology Editors! Together with Teresa Lavacca and in collaboration with Systems Arbovirology, we identify host factors contributing to DMV formation in SARS-CoV-2 infection. Molecular Virology Heidelberg CIID_Heidelberg doi.org/10.1128/jvi.00…

Congratulations to Sarah Goellner Molecular Virology Heidelberg and everyone else CIID_Heidelberg ! This project really evolved into a beautiful story about the role of cholesterol in Zika virus entry and assembly via binding motifs in the M protein! disq.us/t/4ka9d20

🥼 Dr. Ralf Bartenschlager and colleagues at Heidelberg University employed a chemo-proteomics 🧪 approach with a bifunctional #cholesterol probe and showed that cholesterol was closely associated with the #Zika virus structural protein prM. Nature Communications | bitly.ws/32r2v

Congrats to everyone on the most cited researcher list, quite an achievement! Particularly happy for my colleagues Ralf Bartenschlager Molecular Virology Heidelberg, Mathias Heikenwälder Mathias Heikenwälder, Eran Elinav Microbiome & Cancer Elinav Lab at DKFZ and Michael Platten @platten_michael– congratulations!

A new #virus , a mixed cat-dog coronavirus kills thousands of #cats on #Cyprus. It is a cat virus that carries also genetic sequence from a #dog #coronavirus. It demonstrates again that new coronaviruses can emerge easily. We should remain vigilant. science.org/content/articl…

Four Hector Fellows and one Hector RCD Awardee are among the Highly Cited Researchers 2023! Hector Fellows Ralf Bartenschlager, Immanuel Bloch, Patrick Cramer Patrick Cramer, Christoph Klein, as well as HRCDA Awardee Dylan Nelson. Congratulations! 👏 clarivate.com/highly-cited-r…

Several new studies about replication organelles out in Nature Communications from the CIID_Heidelberg ! Solène Denolly Molecular Virology Heidelberg characterizes the proteome of Zika virus ROs and describes mechanisms for several host factors nature.com/articles/s4146…

Cool new method for mechanistic studies in complex lymphoid tissue: Congratulation to Katharina Morath (Fackler lab) for establishing gene editing in ex vivo tonsil cultures that will enable e.g. new quantitative #HIV research sciencedirect.com/science/articl…

Check our colorful paper nature Comm on an all-optical multiplex #antiviral assay for imaged-based high-throughput #screening. Also the foundation for other multiplexed screens & the development of much needed broader-spectrum antiviral drugs. KU Leuven ncbi.nlm.nih.gov/pmc/articles/P…

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress dlvr.it/T5QKQC

New insights into the mechanism of action of NS4B inhibitors, currently the most promising class of #dengue antivirals! Many thanks to my colleagues Molecular Virology Heidelberg, our partners Johan Neyts lab, Systems Arbovirology and J&J Innovative Medicine as well as to our funders! nature.com/articles/s4146…

New insights into the mechanism of action of JNJ-A07, a highly potent pan-serotype dengue virus inhibitor Dominik Kiemel Molecular Virology Heidelberg CIID_Heidelberg #dengue #JNJA07 #virology #antivirals nature.com/articles/s4146…

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08773-xHigh-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus. nature.com/articles/s4158…

Johan Neyts This study is published back-to-back with a paper from J&J describing a molecule with a similar MOA. "A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein" nature.com/articles/s4158… Also with contributions from my UU colleagues! 😃

This is what European Research can do! Kudos!!!!