Sunday musings. Five things I have learned over the years, cemented by the consult service, that every pathologist should consider when releasing diagnoses into the wilderness. 1. Pathologists are morphologists, yes, but much more importantly, they are consultants. Findings that

Enthusiastic eosinophils: I rarely see significant eosinophils in checkpoint-inhibitor associated interstitial nephritis, but this case was the exception. Checkpoint Checkmate.

Rare case from Yale School of Medicine researchers shows that thrombotic microangiopathy should be considered a possibly life-threatening complication in the setting of acute diethylene glycol poisoning. Yale Nephrology Gilbert Moeckel Deepthi Gunasekaran Grace L. Malvar, MD bit.ly/49OIGoX

1. Focal necrotizing lupus arteritis. Plus severe lupus vasculopathy. Can be missed and is unfortunately not part of the lupus classification. 2. Glomeruli showed mesangial lupus nephritis, class II. 40-yr old woman with lupus & rise in serum creatinine,+ lupus anticoagulant.

Giemsa stain glamour shots of Helicobacter helmanii party (looks like cavatappi pasta!) #GIpath #pathoutpic

1st image 2500X EM feat. en face view of fenestrated endothelium, effaced podocytes, and multiple tubulo-reticular inclusions. What are possible conditions that can have these findings if the biopsy is from: 1) native kidney? 2) allograft kidney? #RenalPath

When 1 diagnosis just isn't enough. Pt with sub nephrotic proteinuria and BMI of 40. Glomerulomegaly c/w obesity related glomerulopathy, surprise PLA2R+MN, and thin GBM lesion. Death by 1000 cuts. #renalpath #nephropathy #pathtwitter

Always satisfying to find well developed organizing deposits by EM. This is a case of immunotactoid glomerulopathy. Microtubules in parallel arrays in, >30 nm in diameter. #renalpath #pathtwitter #nephrology

Pancreatic Adenosquamous Carcinoma (#PASC) is an aggressive variant of pancreatic ductal adenocarcinoma (#PDAC), characterized by glandular and squamous differentiation (at least 30% of the neoplasm) & can harbor BRCA/PALB2 mutation. #GIPath #Pathology #PancreaticCancer #Pancreas

Epithelioid GIST with strong KIT staining—> think SDH deficient GIST! - pearl shared by Jason L. Hornick, M.D., Ph.D. #FIGHP2024 BIDMC Pathology Vikram Deshpande Feidi Chen Lisha Wang, MD, PhD Brigham and Women's Pathology

A Rare #RenalPath Case ~ Glomerulus *packed* with histiocytes! ➡️ In Apolipoprotein-E2 associated renal disease 📚 See this review for more reading: kidney-international.org/article/S0085-…

Transplant Arteriopathy ~ In kidney with chronic rejection ➡️ Intimal thickening + inflammation in vessel wall ~ #RenalPath #Transplant #Kidney

This biopsy was performed on a 58 year old female who presented with mild proteinuria. The glomeruli show diffuse and global endocapillary hypercellularity with segmental double contour formation of the capillary loops on silver stain (Fig 1). Immunofluorescence shows mesangial