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Fantastic, powerful initiatives that empower young people with type 1 diabetes and can be a source of inspiration for others around the world. Another milestone contribution in diabetes care in the UK. AMD Associazione Medici Diabetologi SID Italia Stefano Del Prato Amy Jolley

Frailty is no longer just a condition of old age. Our recent article discusses how early onset type 2 diabetes might drive premature frailty with major implications for clinical care and public health.

Significant data⚡️ My take: 1. The quality of care(SoC) at each facility influences DFU outcome 2. Maj Amputations are a clinical decision rather than an inexorable outcome - modifiable (not always avoidable) Giuseppe Maltese Fran Game Joseph L. Mills MD José Luis Lázaro Martínez Marco Meloni

1/ 🧵The Life of Insulin: Insulin is made n the β-cells of the pancreas, where it is folded, processed, and stored in secretory granules. Upon glucose stimulation, insulin is secreted into the portal circulation, giving it direct access to the liver.

Results from an indirect analysis: Tirzepatide (10/15mg) vs semaglutide (2.4mg) in T2D with obesity: 📍4.4–5.3% greater weight loss 📍Up to 2.2× more likely to lose ≥5% weight 📍0.35–0.67% greater HbA1c reductionHead-to-head data still needed. …ubs.pericles-prod.literatumonline.com/doi/10.1111/do…

A new opportunity to improve the management of people with type 2 diabetes mellitus: giving patients the chance to learn from their mistakes! Djordje Popovic Giuseppe Maltese doi.org/10.1177/193229…

The Importance of Resistance Exercise Training to Combat Neuromuscular Ageing #ageing #exercise #muscle pubmed.ncbi.nlm.nih.gov/30724133/

Thrilled to see this published. As the population with type 1 diabetes ages, rethinking care has never been more important. Partha S Kar 🇮🇳🇬🇧🏏🎥 Srikanth Bellary Breakthrough T1D UK Amy Jolley Geraldine Gallen

Frailty: implications for clinical practice and public health. Lancet 2019; 394: 1365–75. via The Lancet

Managing menopause in women with diabetes Iliana C. Lega doi.org/10.15277/bjd.2…

High prevalence of frailty among patients with diabetes undergoing lower extremity amputation. Higher Clinical Frailty Scale scores associated with decreased overall survival, amputation-free survival and leg salvage. Prash Vas sciencedirect.com/science/articl…

GLP-1 receptor agonists - promising treatments for neurodegenerative diseases. Incretins beyond glucose control. Alessandro Morandi Prash Vas Dr Rajay Narain sciencedirect.com/science/articl…

Biological properties of GLP-1 receptor

In adults with T1 diabetes Severe hypoglycaemia is associated with an increased risk of hospitalisation for adverse CVD complications. This risk is significantly reduced in isCGM link.springer.com/article/10.100…

The Fate of Older Adults in Antiquity: Senicide and Its Cultural Legacies. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…

Many older patients are not screened for frailty before surgery. UK study found that 71% of hospitals skip routine frailty checks in over60s. Screening is simple, improves outcomes, and should be standard practice. Via The Standard British Geriatrics Society NHS England Adam Gordon MBE

CGM use is rising, though still slowly, in older adults with T2D. Stark disparities by race, age, and socio-economic status persist. Equitable access to diabetes technology should be a priority, in any country. Diabetes Care, a research journal of the ADA 🌟 #Diabetes #Olderpeople #Technology

Frailty: a global health challenge in need of local action. BMJ Global Health

"One important finding of our study was the high prevalence of confirmed hypoglycemia and the high nocturnal TBR percentage, even though included patients had HbA1c values in the recommended range for older people ..." via JAGS