Standoff

Congratulations ⁦⁦HaGe Sprenger⁩ ! Cool combo of findings and methods, including in vivo Mito-IP. biorxiv.org/content/10.110…

Beyond excited to help start a branch of IOCB Prague in the Boston area. This is only possible because of the amazing generosity and efforts of dozens of people, some very public in their support and many others working behind the scenes. All heroes to me. davidsabatinilab.com

NYT fan of Rapa Nui lately

This is a very important paper.

Unexpected find

🎉

Very cool aging-relevant connections between inflammation and mTORC1 and friends

I’m really excited to share a new pre-print in full collaboration with the lab of John Iafrate Mass General Brigham which was led by two superstars: Diane Yang and Stefan Andrew Harry who developed: Systematic Targeting of Protein Complexes with Molecular COUPLrs.

🧵1/3 Excited to be presenting our paper, CLIPZyme, at ICML Conference this week with itamar. In our paper we introduce a new method to rank enzymes based on their catalytic activity given the reaction of interest. Paper: arxiv.org/pdf/2402.06748 Code: github.com/pgmikhael/clip…

I'm thrilled to join Dana-Farber Cancer Biology Department and Harvard Med Cell Bio as a tenure track assistant professor Sept 2024! The Gu lab elucidates mechanisms underlying cellular homeostasis, with our initial effort on nuclear protein turnover by the ubiquitin-independent midnolin-proteasome pathway

mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction: Cell Reports cell.com/cell-reports/f…

Are you interested to become a leader of independent research? Do it with us! The deadline is approaching.

biorxiv.org/content/10.110… Our new preprint by Ashley Segura ashley segura and Rose Citron dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with Mancias Lab!

1/Out today @nature, a paper from Divya Bezwada and DeBerardinis Lab Children’s Research Institute at UT Southwestern about metabolism in human clear cell renal cell carcinoma (ccRCC). Divya identified an unexpected metabolic change that allows these tumors to metastasize. 🧵below.-RJD nature.com/articles/s4158…

Awesome work from Max Valenstein, MD, PhD, finding essential role for Rag-Ragulator in docking the entire nutrient sensing pathway to the lysosome. And, in complete Rag null cells mTORC1 does not sense nutrients. pnas.org/doi/10.1073/pn…

nature.com/articles/s4158… Excited to share new work form our lab led by Shinya Imada and Saleh Kwaled Saleh Khawaled, PhD demonstrating how a post-fast refeeding drives stem cell mediated regeneration via polyamine metabolites. The work would not have been possible without our great

Very proud of this important work on how thyroid status impacts the brain and behavior. Led by postdoc Dan Hochbaum who assembled quite a team urldefense.proofpoint.com/v2/url?u=https…

For the first time ever, a 13-year-old boy has been cured of a deadly brain cancer The boy’s tumor disappeared after participating in a new clinical trial. “Everolimus, a tablet that’s taken once per day, has been approved in the UK and the US to treat cancers in the breast,

Mitochondriacs! are you completing a MSCA IF by the end of Sept, or did you complete it < than 60 months ago? or did you receive a SOE in the last 24 m? What about a funded 3y non tt ass prof+150-100K grant here in Padua, the cradle of mitochondria? Interested? email me! LS