This article discusses the key publications and findings in the author’s laboratory that helped to identify inflammation as an important factor contributing to interindividual variation in drug metabolism. Read the article here: ow.ly/zvTl50TQMHC. #DMD #pharmacology

The November 2024 Highlighted Trainee Author for DMD is George Trevor. His work focuses on precision medicine and hopes to apply this concept to neurological/psychiatric disorders and the drugs that treat them. Read his work here: ow.ly/MIzk50U6mjP. #pharmacology Western University

ASPET’s Editorial Fellowship Program is accepting applications for its 2025 class. Fellows will learn important elements of the editorial process, including all aspects of the submission process, peer review, and editorial decisions. Apply by Dec 11: ow.ly/4IMN50U7SMT.

The GSK group localized a STING agonist for hepatitis B, namely GSK3996915, and its metabolites in mouse liver through MALDI-MS imaging which supports understanding of pharmacokinetic properties of the drug in early discovery stage. Read more here: ow.ly/qG5Q50UgRJS

Experts found abiraterone as a “weak” OATP1B inhibitor (Ki 3.9 µM). Further PBPK simulation and clinical studies showed the absence of OATP1B-mediated DDI between its endogenous biomarker coproporphyrin I and abiraterone in cancer patients. Read it here: ow.ly/6lPe50UgSbb

The December 2024 Highlighted Trainee Author for DMD is Laura de Jong, a PhD student at @unileidennews. Her research focuses on how non-genetic factors impact drug metabolism. Read her work here: doi.org/10.1124/dmd.12…

Novartis scientists report their comprehensive studies on the ADME/PK of icenticaftor (QBW251), a drug candidate for the treatment of chronic obstructive pulmonary disease (COPD). Read the article here: ow.ly/rVf850Ul7B7. #pharmacology #drugdevelopment

Mouse transporter Abcc4 does not transport arsenic substances or protect against cytotoxicity, indicating functional differences between human ABCC4 and mouse Abcc4 likely contributing to species differences in arsenic toxicokinetics. Read more here: ow.ly/bJWR50Ul7ZT

Big news! ASPET's journals are now live on the Elsevier platform! This partnership will: 🔬 Expand the journals’ global reach 🔬 Increase the usage of innovative technologies 🔬 Provide more opportunities to share cutting-edge science Learn more: aspet.org/aspet/journals

The January 2025 Highlighted Trainee Author for DMD is Chukwunonso Nwabufo, a PhD candidate at @uoftpharmacy. His research focuses on understanding how diseases like COVID-19 interfere with the body's ability to process drugs. Read his work here: doi.org/10.1124/dmd.12…

Dr. Qingcheng Mao’s former and current lab members summarize their team contributions to research on efflux transporters and drug disposition, especially the roles of P-gp and BCRP in maternal-fetal exposure to various xenobiotics. Read the article here: doi.org/10.1124/dmd.12…

Joe Lim, a PhD Candidate at @UWSPH, is the February 2025 Highlighted Trainee Author for DMD. His research focuses on the liver, and the interactions of its various cell types and their specialized functions: doi.org/10.1016/j.dmd.….

This article reports a systematic characterization of cell-type-specific and zonal distribution of ADME gene transcripts in mouse liver that may provide insight into xenobiotic metabolism and disposition from a new angle. Read it here: doi.org/10.1016/j.dmd.…

Pollinzi et al. revealed a significant lower P-glycoprotein level in preterm placentae of autoimmune diseases subjects along with the dysregulation of multiple cytokines and associated pathways, which could aid in precision medicine: doi.org/10.1016/j.dmd.…

Pooja Hegde is a Highlighted Trainee Author for DMD. She hopes her work will address gaps in the DMPK field and provide a better understanding of risk prediction and enhance screening of compounds for DDIs early in the discovery stage. Read here: doi.org/10.1016/j.dmd.…

Ankit Balhara, a Postdoctoral Scholar at the @uw_pharmacy, has been selected as Highlighted Trainee Author for DMD. “My work has the potential to enhance drug safety and protect patients from unintended adverse effects,” he shares. 🔗 Read more: doi.org/10.1016/j.dmd.…

Heylen et al. report the impact of perfusate composition on drug disposition in isolated perfused rat liver model, emphasizing and enabling the use of optimal experimental conditions to improve IVIVE for predicting hepatic clearance. Read the article: doi.org/10.1016/j.dmd.…

This article overviews the tissue localization, species differences and genetic variations of organic cation transporter 2, as well as other factors that may affect OCT2 activity relevant to tissue toxicity and systemic exposure to its cationic substrates: doi.org/10.1016/j.dmd.…

Tim Tsang, a PhD student at UW School of Pharmacy, is the May Highlighted Trainee Author for DMD. “I hope my research will establish a foundational understanding of how inflammation and pregnancy influence the expression and activity of renal drug transporters." doi.org/10.1016/j.dmd.…

In this article, researchers report the utility of siRNAs to effectively and selectively knock down individual P450 enzymes for reaction phenotyping in primary human hepatocyte spheroid cultures, being an addition to existing tools for ADME/PK research. 🔗doi.org/10.1016/j.dmd.…