Acinar Cell Carcinomas of the #Pancreas. Well-circumscribed with scant stroma and composed of monotonous neoplastic cells with polarized nuclei, frequent mitotic figures and prominent nucleoli. Positive for trypsin and BCL10. #Pathology #GIPath #PancreaticPath #PancreaticCancer

2) Ductal Prostatic adenocarcinoma Columnar pseudostratified *endometrioid-like Also a bad actor

Ductal adenocarcinoma of the #prostate, if with tumor cell necrosis is upgraded from Gleason pattern 4 to pattern 5. Note the characteristic tall columnar cells with palisaded high-grade nuclei. #GUPath

Prostatectomy. Prostatic adenocarcinoma with great PIN-like morphology (here with perineural invasion).

Cystic and papillary variant of pancreatic ductal adenocarcinoma Female, 60's, pancreatic head mass. I loved the gross appearance and the scanning power view of this weird and interesting variant 😃

An unusual form of Ductal Adenocarcinoma of #prostate with clear cytoplasm. #GUPath

Uncommon example of lymph node with metastatic ductal adenocarcinoma of #prostate. #GUPath

Unique central presentation of Ductal adenocarcinoma of #prostate as urethral polyp at veromuntanum. These tumors were once thought to be “endometrioid” adenocarcinoma that arises from prostatic utricle, suggested to be the male homolog of female uterus. #GUPath

Isolated pure urethral/periurethral Ductal adenocarcinoma polyp at #prostate verumontanum on RP. A separate 3+3 cancer present at peripheral zone (3% volume, not shown). Pre-RP biopsy was 3+3. How will you grade this focus of ductal adenocarcinoma? Or will you grade? #GUPath

Eye-catching transition and intimate intermingling of Acinar and Ductal adenocarcinoma of #prostate. 👉Ductal adenocarcinoma has stratified taller columnar cells with higher grade nuclei. #GUPath

Haven't posted in a while! Classic ductal adenocarcinoma of the prostate ✅Papillary & cribriform architecture most common ✅Columnar pseudostratified cells ✅Majority admixed with acinar adenoca ✅Central tumors may present as polypoid urethral lesion #gupath #pathresidents

Another 2-in-1 in #prostate TUR involving separate tissue chips: 👉 Neuroendocrine carcinoma 👉 Acinar adenocarcinoma GG5 👉Nice selective staining of synaptophysin and NKX3.1. 👉Most neuroendocrine carcinomas had prior or concomitant acinar adenocarcinoma. #GUPath

High-grade PIN or carcinoma or both? Answer in comment. #Prostate #GUPath

That is an excellent example of PIN-like Carcinoma. - glands w pseudostratified epithelium resembling a ductal adenocarcinoma. - Favorable prognosis. It´s assigned as Gleason score 3 + 3 = 6. - IHC (pic): p63 #uropath #pathology

🏆PIN-like prostate adenocarcinoma Incidental finding in TURP for BPH IHC - AMACR/p63/KRT903 cocktail #GUpath

27♂️ w/ painful mass & paresthesias Can you figure it out? Or is it... #tooFARtodiagnose? 🤔 📢 Answer posted tomorrow (9/10) #bstpath

From the "you don't see this every day" file, a cluster of subcutaneous degranulating mast cells in a case of severe fatal anaphylaxis. #pathology #pathtwitter

70s F 1.8cm renal mass. Dx? #PathX #PathTwitter #GUpath

Grades of Pancreatic Intraepithelial Neoplasia (PanIN), precursor to most #PancreaticCancer #Pathology #GIPath

Beautiful high grade prostatic intraepithelial neoplasia (PIN), micropapillary type.