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Interested in Cullin-RING E3 ligase networks? We developed synthetic antibodies specific for activated CRLs and used them to profile how CRLs adjust to cellular stimuli and small molecule degraders. Peter J Murray Matthias Mann Lab Sachdev Sidhu Max Planck Institute of Biochemistry (MPIB) bit.ly/3kjT57I

A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation biorxiv.org/cgi/content/sh… #biorxiv_immuno

CoxLab and Coon Lab scientists succeeded in developing a new method to generate a more detailed #proteome than ever before, providing insights into how #GeneticVariants and #SpliceVariants in humans impact the proteome. Published in Nature Biotechnology nature.com/articles/s4158…

Excited to share the latest work from my time in the Garcia Lab: Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR), a Nanobody based, modular mix & match Targeted Protein Degradation (TPD) toolbox to target cell surface receptors. ACS Synthetic Bio pubs.acs.org/doi/10.1021/ac…

The Human Cell-Surface Interactome Project, deposited by Chris Garcia's lab, is now available hubs.la/Q01Jg1-S0

Congrats to Alex on his Notch paper published in Science Signaling! Special thanks to our fantastic team - Emily, Lena, Drew, Julia and collaborators. Click here to read the paper. science.org/doi/10.1126/sc…

Want to hunt down the cullin-RING E3 #ubiquitin ligases involved in your favorite pathway or #DegraderDrug? Exited that our story on probing active (neddylated) #CRL E3 complexes using conformation specific probes is out now! nature.com/articles/s4158…

Excited to the see the diversity of and emerging successes for extracellular protein degradation (eTPD) to pair with the established successes of intracellular protein degradation (iTPD). Kaan Kumru and I are thrilled to share this review! ...no protein is safe!

Extracellular targeted protein degradation: an emerging modality for drug discovery bit.ly/489BXVZ This new review by Jim Wells & Kaan Kumru covers systems for extracellular targeted protein degradation, including LYTACs, ATACs, AbTACs, PROTABs and KineTACs

Today we remember and celebrate the life of Bill Weis. Our friend, colleague, & mentor. We scientists are lifelong learners by temperament & necessity. Bill fueled our learning daily. 1/n

What if you could design binders to specific spots/motifs on target proteins: conserved epitopes on pandemic viral phosphoproteins, disordered regions on dysregulated transcription factors, or even breakpoints on fusion oncoproteins? That would unlock unprecedented specificity

Such a amazing story, congrats to Vince Luca and the whole team

Just before the New Year: BindCraft v1.5! Please fill out this form to request new features and help us make BindCraft even better. forms.gle/XsGHDCyHtczVba…

Excited and proud to have this paper published with Nature Communications today! Great project led by Juan L. Mendoza at UChicago Pritzker School of Molecular Engineering and HHMI. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results! nature.com/articles/s4146…

Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling biorxiv.org/content/10.110… #biorxiv_biophys

Induced proximity at the cell surface - Carolyn Bertozzi go.nature.com/4c9hu6M

…high jacking the UPS, great read featuring bifunctional and multifunctional degraders: sciencedirect.com/science/articl…

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a tweetorial today, but enjoy and happy to get any feedback on this story. biorxiv.org/content/10.110…

Another great collab with John Janetzko, @rvshivand, Jonathan, the Kobilka lab and Greenstone Biosciences, stay allosterically tuned… biorxiv.org/content/10.110…