Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.110…

Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. Shoval Miyara Miri Adler Eldad Tzahor

New preprint countdown! Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected strategy with ancient origins. Stay tuned!

LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.

Very excited this work is out in Nature Physics. A wonderful collaboration between my group Massachusetts Institute of Technology (MIT) and PhysicsOfLifeLMU.

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…

🚨📢Fresh off the press and featuring new exciting experiments! 🧪 We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling doi.org/10.1016/j.stem… B2B with Alba Villaronga teamstembryo : doi.org/10.1016/j.stem…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…

How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by Pau Guillamat IBEC biorxiv.org/content/10.110…

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by Nimesh Chahare🙌. Theory by Marino Arroyo and team. biorxiv.org/content/10.110…

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025.0… 🧵with pressure control, multiscale buckling, patterned wrinkling

In January 2026, I will be joining Berkeley UC Berkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry College of Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National

Have you always wanted to take a protein from its native context and make it work elsewhere? Our novel sampler computationally “cytosolize” a secreted enzyme while maintaining its structure, generalizable to other multi-objective guided generation tasks biorxiv.org/content/10.110…

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos? I’m Arthur Michaut , and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

Our logo is a cell reaching out 🧫, a figure in motion 🏃‍♂️, and a network of signals 🌐! It captures our research: Mechanism (Discovering principles of life), Function (Elucidating the roles of living systems), and Design (Building synthetic circuits). bit.ly/ShiyuXiaLab

♻️ Please share, friends and colleagues! 📢 Hiring postdocs for my lab UC Berkeley. Let’s make discoveries as iconic as the Campanile! 👉 Apply: bit.ly/ShiyuXiaLab Seeking: 🧪 Biochemists 🧬 Structural Biologists 🛠️ Synthetic Biologists 🐭 Animal Model Experts

I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.110…

Keystone symposia on stem-cell-based embryo models (SCBEMs). Join us in discussing the development, measurement, and manipulation of SCBEMs in California in Feb 2026! keystonesymposia.org/conferences/... Scholarship/ShortTalk Deadline: Oct 21 Early Registration: Dec 18 (Save $200!)

“What’s past is prologue” — excited about chromatin recording by synthetically engineering recruitment of adenine methyltransferases in living cells. Will enable one to correlate past states with subsequent fate decisions. New work from the virtuosic Yodai Takei See thread.