5-HMSiR-Hoechst SMLM performance is fast enough to monitor chromatin dynamics with localization precision of ~5nm. Enjoy #FluorescentFriday image reconstructed with SVI Huygens localizer. Just published in Chemical Communications : doi.org/10.1039/D0CC06…

Watt Webb, biological imaging techniques pioneer, dies | Cornell Chronicle news.cornell.edu/stories/2020/1… via @AddThis

Build your own smfBox - everything you need to build and run accurate and dynamic smFRET experiments - cheaply! #openAccess #openSource #openMicroscopy Paper here: rdcu.be/b9Prx And a great intro video here from the master of microscopy nightmares DrLachie. Enjoy!

In a major scientific breakthrough, the latest version of #AlphaFold has been recognised as a solution to one of biology's grand challenges - the “protein folding problem”. It was validated today at #CASP14, the biennial Critical Assessment of protein Structure Prediction (1/3)

Congratulations to Aakash Basu whose postdoctoral work on measuring DNA mechanics on the genome scale has just been published in Nature! nature.com/articles/s4158…

We finally joined modernity and created GitHub for our single molecule data acquisition and analysis packages. Big thanks to Ting-Wei Liao! github.com/Ha-SingleMolec…

[Thread] I am happy to share a new preprint from our lab. The work was led by PhD student Derek Hart Derek Hart and co-authored by former PhD student Jiyoun Jeong Jiyoun Jeong and my colleague JC Gumbart GT School of Physics. biorxiv.org/content/10.110…

The field of Genomics is due another revolution, after having Illumina as a dominant players in the last 10-15 years. This year announcements, culminating in the AGBT22 meeting, have been akin to a Cambrian explosion moment for NGS, with lots of new companies entering the fore.

New research from the Cornell Physics lab of Michelle Wang provides valuable mechanistic insights for broad applications of #CRISPR gene-editing technology. NatureStructMolBiol CornellArts&Sciences Cornell Engineering news.cornell.edu/stories/2022/1…

Beautiful work from my colleague Porter Hall from Michelle Wang lab at Cornell on the molecular mechanism of the polarity of CRISPR Cas barrier to transcription is now online in NSMB. I helped a bit with troubleshooting a transcription assay. nature.com/articles/s4159…

A new paper from Michelle Wang, Tung Le & colleagues (Cornell Physics Lab of Atomic & Solid State Physics @ Cornell HHMI) reveals the poisoning mechanism of the chemotherapeutic agent #etoposide on topoisomerase II using #singlemolecule biophysics methods. Open access: nature.com/articles/s4158…

Happy to see my paper on the chemotherapeutic drug etoposide finally out in Nature Chemical Biology Nature Chemical Biology ! Access free article at nature.com/articles/s4158… Also check our research briefing of the work nature.com/articles/s4158…

Inspired by nature, sourced from nature, designed for nature, and published in nature ! Biodegradable morphing robots are "gone to earth".

Magnetism May Have Given Life Its Molecular Asymmetry quantamagazine.org/magnetism-may-… via Quanta Magazine

New interesting paper from the Michelle Wang lab on topoisomerase II dynamics on DNA and chromatin, focusing on the low-torsion pre-buckled state #NatureComms Nature Communications nature.com/articles/s4146…

Our new preprint detailing an effective surface passivation method to work with large nucleosome fibers anchored to a surface and study topoisomerase II's enzymatic activity on a twisted chromatin substrate. Original article: lnkd.in/gtArd28C. biorxiv.org/content/10.110…

RNA Polymerase II is a Polar Roadblock to a Progressing DNA Fork biorxiv.org/cgi/content/sh… #biorxiv_biophys

Very interesting new preprint from the Wang lab on the head-on collision of eukaryotic RNA polymerase Pol II and an approaching DNA fork that mimics a replication fork. RNA Polymerase II is a Polar Roadblock to a Progressing DNA Fork biorxiv.org/content/10.110…

We are thrilled to introduce 2 posters next week at #SITC2024 showcasing the latest data generated on the G4X. The posters will be presented on Saturday November 9th and will highlight the novel Direct-Seq technology and the G4X's high-resolution in situ multiomic capabilities.