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Our #preprint on Pitx1 & Liebenberg syndrome with @BompadreOl98894 is out. Key findings: Phenotypic severity tied to proportions of Pitx1 overexpressing cells, not transcription level. Pitx1 transcription doesn't drive enhancer-promoter interactions. 1/X biorxiv.org/content/10.110…

Our #preprint on gene regulatory trajectories with Raquel Rouco, PhD. is out! We find that different enhancer repertoires act transiently and subsequently to sustain cognate gene expression over time. And more on E-P interactions and digit formation! 1/X biorxiv.org/cgi/content/sh…

This is gonna single handedly kill the german academic competence. Without offering resources to provide the said permanent contracts, this ruling will put immense pressure on budding scientists in their formative phases.

We are 60 years young and look forward to the next 60 years of molecular genetics at@MaxPlanckPress! We are celebrating with a scientific symposium and a ceremony on 30/31 May. Celebrate with us and register by April 30! Please share! #MPIMG60years molgen.mpg.de/60th-anniversa…

Check out our line-up of guest speakers and honorary guests for the 60th anniversary symposium of our institute! In the coming weeks we will present guest speakers here on X - stay tuned! #MPIMG60years

Next-gen Synthetic Genomic Reconstitution🧬!!! Congrats to Raquel Ordoñez, Weimin Zhang and the rest of the Dark Matter Project team! Check out more publications here: thedarkmatterproject.org/publications

It was a pleasure to write this review together with Nelly Kanata and Rachel Duffie Rachel Duffié from the Lomvardas lab on the principles that govern monoallelic expression of olfactory receptors and Xist for Development

Today we report in Nature Biomedical Engineering the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13) drive.google.com/file/d/1WDMVqL…

Trunk-like-structures on the cover of Developmental Cell! 🤩Check out the paper doi.org/10.1016/j.devc…. Fantastic outcome of a project I was very lucky to collaborate on, and that is very dear to me for multiple reasons 🧵

Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of Denes Hnisz, VingronLab and Graf Lab published today in Nature Cell Biology nature.com/articles/s4155…

the Kraushar Lab had a blast hosting Jun Wu Jun Wu Lab UT Southwestern Medical Center here at MPI for Molecular Genetics in Berlin breaking boundaries in the stem cell field, and engineering the future of developmental, evolutionary, and medical biology 🐁🐀🐎🐄🐒😀 🍻 from your friends in Berlin!

In times of a rat race to make more "perfect" and complex embryo models, we hope our paper inspires researchers to take a step back, and (re)think why we develop models in the first place: to help us learn and understand. (9/n)

How does chromatin fold in different species? Is there an ubiquitous mechanism of chromatin folding in all species? We review published data to investigate the "Evolution and function of chromatin domains across the tree of life". rdcu.be/d1CxC

🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺 Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!! Ivana Jerković Michael Florian Szalay 🧬 Blanka Majchrzycka Giacomo Cavalli MPI for Molecular Genetics @berlinnovation InstituteHumGenetics nature.com/articles/s4159…