🔔🔵After nearly 5 years from its conception with Johannes Bohacek, I'm proud to share that our paper on opto-fMRI of the Locus Coeruleus is finally published in Nature Neuroscience! Huge thanks to everyone who contributed—including reviewers and editors! rdcu.be/dT3kB

🚨🔵Our latest #LocusCoeruleus paper out! It tackles the old tonic vs. phasic firing debate, combining optogenetics with fMRI. Amazing collaborator Valerio Zerbi was the driver behind this work, and our fabulous PhD-stars Christina Grimm & Sian Duss 🥳🎉

lakecomodesignfestival.com/en/designers/a…

If you’re attending #sfn2024 #SfN24 and would like to chat about our recent publication about #orexin and exercise/eating decisions, visit me Monday morning at PSTR185.06!

Yay. Finally it is out! If you are curious about how the brain controls the jaw in response to hunger you should read this: nature.com/articles/s4158…

This from a really nice review Neuron (doi below) on Neurobehavioral meaning of pupil size. How far are we from measuring these things via phone cameras along with eye tracking to match content foraging, physiology & dwell times etc. ? Seems doable & valuable.

"In a world of change, the learners shall inherit the earth, while the learned shall find themselves perfectly suited for a world that no longer exists." - Eric Hoffer, philosopher and author

Huge congrats to Karyna M. 🇺🇦 for her paper published today in Science Magazine! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠science.org/doi/10.1126/sc… 1/7

SleepLüthiLab uncovers a dual role of #locus Pierre-Hervé Luppi in #sleep -> 1) its strict gatekeeper role for the sleep cycle 2) the partial brain-body arousals it generates. Powerful minds behind all this: Alejandro Osorio-Forero Georgios Foustoukos Romain Cardis nature.com/articles/s4159…

Our new paper is out in Cell Reports We show an inhibitory response of Orexin receptor type 2 (Ox2R) in a subset of MCH neurons. doi.org/10.1016/j.celr…

You just can't leave the dessert even though you're full? 🍰 Blame it on your POMC neurons!🧠 (details ➡️🧵) Congratulations to Marielle Minère, Henning Fenselau and all other authors for their newest publication Science Magazine ! 🎉 science.org/doi/10.1126/sc… 1/3

Here's our latest issue: cell.com/neuron/current The cover is for a Perspective piece by Lüthi & Nedergaard who discuss microarousals, and propose an inverted U-shaped relationship to reconcile their essential and disruptive roles: cell.com/neuron/fulltex… Cover by Nadia Alzoubi

Lifestyle is a stronger predictor of aging and mortality than genetics. A new Nature study of ~500,000 people found: 🎯 17% of mortality variation was linked to lifestyle (exposome). 🧬 <2% of was explained by genetics. Here’s what you need to know 👇🧵 1/10

Thinking isn’t free, it costs 1000s of ATPs per bit. Complexity means more bits. Reduce complexity, or pay for it? Hypothalamic neurons have an answer: biorxiv.org/content/10.110…

Newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating decision policy complexity. Huge thanks to my supervisors Denis Burdakov and Rafael Polania biorxiv.org/content/10.110…

How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint): biorxiv.org/content/10.110…

Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab! biorxiv.org/content/10.110…