I’m excited to introduce our Retro-Cascorder, out today in nature! This molecular device logs barcoded receipts of gene expression in a temporal genomic ledger. Sequence the ledger --> recover the history of gene expression. nature.com/articles/s4158…

Party last night of a truly great meeting #hypogrc Hypothalamus Gordon Research Conference 2024

Did you know there are lots of similarities between the innate immune systems of animals/plants and the phage defense systems in bacteria? Check out our new study by the amazing trio Alex (Linyi) Gao, Max Wilkinson, and Jonathan Strecker. Congratulations! science.org/doi/abs/10.112….

Had a lot of fun working with Keith, Luis de Lecea and Soltesz Lab on this. Monitoring distinct cell types during focused ultrasound neuromodulation, which we show can suppress seizure activity. Definitely a useful tool! pnas.org/doi/10.1073/pn…

Mesolimbic dopamine release conveys causal associations science.org/doi/10.1126/sc…

Speakers and preliminary program have been confirmed for the 2023 Neuromodulation GRC and GRS--join us for an amazing meeting! 🏔️🔬🧠🥳

Why Does My Sleep Become Worse as I Age? nytimes.com/2022/12/27/wel…

New paper by the incredible Julia Cox & team! "A neural substrate of sex-dependent motivation" (spoiler: sex differences in motivation to perform a decision-making task are mediated by ACC->DMS neurons) nature.com/articles/s4159…

The first paper from our lab -- a review on the inputs to and outputs from the brain's biological clock, the suprachiasmatic nucleus. mdpi.com/2079-7737/12/4…

Our new Neuron review Luis de Lecea Neuron reconsidering classic view of sleep as global & stationary doi.org/10.1016/j.neur… Fusing evidence for spatiotemporal dynamics & neuromodulatory heterogeneity ➡️ new view on states: functions, mechanisms, experiments, interventions

1/14 How does sleep help memory? we developed closed-loop deep brain stimulation during sleep in human prefrontal cortex w/ timing based on hippocampal activity TLDR: boosting hippocampus-cortex coordination improves memory Nature Neuroscience | rdcu.be/ddxxR

facultypositions.stanford.edu/en-us/job/4946…

Now online! Stepwise emergence of the neuronal gene expression program in early animal evolution dlvr.it/SwLzrB

It all started with Neuropeptides.

Fresh off the press ! Mentor-Mentee, reunited ! with Luis de Lecea Sleep and the hypothalamus science.org/doi/full/10.11…

neuroscience.stanford.edu/news/why-sleep…

Neurophysiological and behavioral synchronization in group-living and sleeping mice: Current Biology cell.com/current-biolog…

Apply ASAP to attend the 2024 Hypothalamus GRC! Please indicate your interest in presenting a poster, short talks will be selected from the poster abstracts. Applications are being considered on a rolling basis - the meeting is capped at 200 people so please apply early! #HypoGRC

Happy to share our latest paper in Neuron by Murphy et al. A significant step towards optimization of focused ultrasound neuromodulation. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…