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Amazing work from New England Biolabs (New England Biolabs) Programmable Cleavage of Double-stranded DNA by Combined Action of Argonaute CbAgo from Clostridium butyricum and Nuclease Deficient RecBC Helicase from E.coli biorxiv.org/content/10.110…

Congratulations to New England Biolabs scientists on this Breakthrough publication! Additionally exciting is that our founder Donald Comb is an author on this paper🧡

The @ettwiller lab adjusted Illumina library preparation protocol with an additional alkaline buffer incubation step to reveal m5C methylation specificity in bacteria. RIMS-seq is a simple approach broadly applicable to bacterial genomics. Chloé Baum academic.oup.com/nar/advance-ar…

Congratulations to New England Biolabs scientists Mehmet Berkmen and Maria Peñil Cobo who received second place in the 2021 Merck Technology Symposium for their Bacillus Bloom!

I am excited to introduce the CapTS-seq method, a less biased sequencing method for simultaneous quantification of small RNA and fragmented mRNAs. A great collaboration with my NEB colleagues of Correa's Lab and Guan's Lab academic.oup.com/nar/advance-ar…

another great collaboration with my New England Biolabs colleagues on using immobilized enzymes for enhanced Oxford Nanopore direct RNA sequencing that enables low-input (50ng) sequencing, more accurate transcriptome profiling and improved pathogen detection. onlinelibrary.wiley.com/doi/full/10.10…

⚡️Out in RNA ⚡️ Hopefully a good resource for everyone interested in using Oxford Nanopore RNA-seq in prokaryotes

I really enjoyed working on this project and lots of gratitude to @ettwiller and Bo Yan! Methyl-SNP-seq is not only a cool idea, but most importantly, it is very useful and works nicely! biorxiv.org/content/10.110…

📢The highly diverse antiphage defence systems of bacteria Georjon & Bernheim provide an overview of the molecular diversity of the most recently discovered bacterial antiphage defence systems and discuss their evolution and the ecological impact of their diversity.

another exciting work from our Research Bioinformatics Group New England Biolabs "Sensitive remote homology search by local alignment of small positional embeddings from protein language models". Big kudos to @TrichomeDoctor and our summer intern Meghana Peshwa! biorxiv.org/content/10.110…

Our work on discovery of a large and highly diverse set of cytosine deaminases is published in Molecular Cell doi.org/10.1016/j.molc…, yielding new opportunities for biotech and genome engineering applications. Kudos to Apobecus Epimarkus @TrichomeDoctor & great collaborators New England Biolabs

excited to present Domainator: a flexible and modular software suite for domain-based annotation and neighborhood analyis: github.com/nebiolabs/doma…. And our preprint of its usage for identifying proteins involved in antiviral systems biorxiv.org/content/10.110…