Coolest work from my scientific&life idol Yu Mu ! Wish I could have opto-genetic control of my glia cells for giving up...

Creative work from Chris King@JLS_lab observing membrane tethering factors partitioned at organelles membrane contact sites using hypotonic cells system!

We are pleased to share a collection of some of our most exciting and most read articles about RNA cell biology bit.ly/2STHJFK

I think I discovered the mechanism of autophagy in this 8 nm FIB-SEM stack of embryonic STEM cells!

Aacck! Very excited our paper is online today Cell 🤓 Wonderful collaborations with Susanne Bechstedt & Thomas (in vitro assays), Al Burlingame & Jose Oses (proteomics), and Huy Nguyen (behavior). cell.com/cell/fulltext/…

When I was at interviewing at Janelia I had the chance to see some of this data and it completely bowled me over. Some of the best EM and LM i've ever seen. The preprint is now out, and it's stunning. Just look at this movie. Way to go David Hoffman! biorxiv.org/content/10.110…

THE BEST correlative cryo-SR(SIM&SMLM)/ FIB-SEM from David Hoffman David Hoffman! Mind blowing every single movie!

5 years of work and a huge amount of effort from every one involved, particularly Gleb: biorxiv.org/content/10.110…. Definitely work that could only be done at HHMI | Janelia.

This imaging platform brings together 3D super-resolution fluorescence microscopy and electron microscopy—and it works on whole cells preserved cryogenically. It’s revealing the fine inner structure of cells in new detail. Read (and watch) more here: biorxiv.org/content/10.110…

A new imaging method follows young neurons in a developing zebrafish as they travel across the embryo and organize themselves into circuits. Read the latest work from Philipp Keller’s lab, published today in Cell. janelia.org/news/how-neura…

Fern Sha engineered a new way to mark active neuron ensembles using light+calcium and then erase the signal to mark a new ensemble under different conditions. Check out the rsCaMPARI preprint: biorxiv.org/content/10.110…

I’m happy to share this work on how cell fusion promote a cell differentiated state through plasma membrane remodeling and changes in bioenergetics. “Transcriptional reprogramming in fused cells is triggered by plasma-membrane diminution biorxiv.org/content/10.110…

Our paper on YAP phase separation is finally out! Thanks to our wonderful collaborators ⁦Lippincott-Schwartz Lab⁩ Natalie Porat-Shliom⁩ ⁦Shahar Sukenik⁩ and the Liu Lab ⁦HHMI | Janelia⁩ ! nature.com/articles/s4155…

Our (Jaime de Juan-Sanz) paper is out today! Here, we show how mitochondrial calcium uptake stimulates ATP synthesis at the synapse through a mechanism that relies on differential regulation of MCU in neurons. cell.com/neuron/fulltex… Interested? My lab is recruiting!

I am excited to share our thoughts on the organization principles of eukaryotic messenger ribonucleoproteins in this fun essay Roy Parker and I wrote this year: bit.ly/2QxYPs3. Looking forward to seeing what the RNA community thinks! Happy New Year!!

Presenting: The most detailed map yet of the fruit fly brain. Janelia’s FlyEM team has traced the paths of some 25,000 neurons in the fruit fly brain and pinpointed the places where they connect. Now, all the data is available online for free. janelia.org/news/unveiling… #hemibrain

Excited to share our new study: nature.com/articles/s4146…. m6A is thought to play a role in targeting RNA to stress granules, but we showed m6A provides a limited effect. This supports the idea that bulk RNA targeting to stress granules is driven by non-specific mRNP condensation.